University of Siena, University of Siena, affiliation not provided to SSRN, Azienda Ospedaliera Universitaria Senese, University of Siena, University of Siena, University of Padua, University of Padua, University of Milan, affiliation not provided to SSRN, Università degli Studi di Bari “Aldo Moro” (UNIBA), University of Rome Tor Vergata, University of Campania Luigi Vanvitelli, Humanitas University, University of Siena, affiliation not provided to SSRN, University of Milan, University of Rome Tor Vergata, University of Campania Luigi Vanvitelli, University of Siena, affiliation not provided to SSRN, Fondazione Policlinico Universitario Agostino Gemelli IRCCS and University of Siena