Behavioral Disinhibition and the Development of Early-Onset Addiction: Common and Specific Influences

Posted: 6 Jun 2008

See all articles by William G. Iacono

William G. Iacono

University of Minnesota - Twin Cities - Department of Psychology

Stephen M. Malone

University of Minnesota - Twin Cities - Department of Psychology

Matt McGue

University of Minnesota - Twin Cities - Department of Psychology

Abstract

Research on substance use disorders is often compartmentalized, focused on understanding addiction to one substance or substance class at a time. Although this approach has contributed significantly to knowledge about addictions, early-onset substance use disorders appear to share common etiology with each other and with other disorders, traits, behaviors, and endophenotypes associated with behavioral disinhibition. We propose that a common genetic liability to behavioral disinhibition underlies the co-occurrence of these externalizing attributes. This liability is expressed in part through brain mechanisms related to cognitive control, impulsivity, and sensitivity to reward, all of which are maturing during adolescence. During this important transitional period, problem behaviors emerge, including the initiation of substance use. Exposure to various environmental risks further amplifies the risk associated with the common liability, increasing the likelihood of addiction generally. Specific environmental and genetic factors ultimately contribute to the differentiation among externalizing disorders.

Keywords: externalizing, endophenotype, genetic liability, environmental risk, adolescent brain

Suggested Citation

Iacono, William G. and Malone, Stephen M. and McGue, Matt, Behavioral Disinhibition and the Development of Early-Onset Addiction: Common and Specific Influences. Annual Review of Clinical Psychology, Vol. 4, April 2008, Available at SSRN: https://ssrn.com/abstract=1141398

William G. Iacono (Contact Author)

University of Minnesota - Twin Cities - Department of Psychology ( email )

Minneapolis, MN 55455
United States

Stephen M. Malone

University of Minnesota - Twin Cities - Department of Psychology ( email )

Minneapolis, MN 55455
United States

Matt McGue

University of Minnesota - Twin Cities - Department of Psychology ( email )

Minneapolis, MN 55455
United States

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