Integrated Research into the Nanoparticle-Protein Corona: A New Multidisciplinary Focus for Safe, Sustainable and Equitable Development of Nanomedicines

Nanomedicine, Vol. 3, No. 6, pp. 859-866, 2008

8 Pages Posted: 12 May 2009 Last revised: 9 Feb 2014

Thomas Alured Faunce

Australian National University; Australian Research Council

John White

affiliation not provided to SSRN

Klaus I. Matthaei

affiliation not provided to SSRN

Date Written: December 10, 2008

Abstract

Much contemporary nanotoxicology, nanotherapeutic and nanoregulatory research has been characterised by a focus on investigating how delivery of engineered nanoparticles (ENPs) to cells is dictated primarily by components of the ENP surface. An alternative model, some implications of which are discussed here, begins with fundamental physicochemical research into the interaction of a dynamic nanoparticle-protein corona (NPC) with biological systems. The proposed new model also requires, however, that any such fresh NPC physicochemical research approach should involve integration and targeted collaboration from the earliest stages with nanotoxicology, nanotherapeutics and nanoregulatory expertise. The justification for this integrated approach, we argue, relates not just to efficiency and promotion of innovation, but to an acknowledgement that public-funded basic physicochemical research in particular should now be accepted to incorporate strong higher order public goods elements from its inception, not merely after product development at the technology transfer stage. Issues, in other words, such as university research co-operation, commercialization and intellectual property (IP) protection, safety and cost-effectiveness regulatory assessment, as well as technology transfer should not be viewed as second tier considerations even in a ‘blue sky’ NPC basic research agenda.

Keywords: Nanoparticle-protein corona, nanotoxicology, technology transfer, cost-effectiveness, safety regulation, nanomedicine

Suggested Citation

Faunce, Thomas Alured and White, John and Matthaei, Klaus I., Integrated Research into the Nanoparticle-Protein Corona: A New Multidisciplinary Focus for Safe, Sustainable and Equitable Development of Nanomedicines (December 10, 2008). Nanomedicine, Vol. 3, No. 6, pp. 859-866, 2008. Available at SSRN: https://ssrn.com/abstract=1402408

Thomas Alured Faunce (Contact Author)

Australian National University ( email )

Canberra, Australian Capital Territory 0200
Australia
61 2 61253563 (Phone)

Australian Research Council

Canberra, ACT 0200
Australia

John White

affiliation not provided to SSRN

Klaus I. Matthaei

affiliation not provided to SSRN

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