Gene by Environment Interaction in Asthma*

Posted: 10 Aug 2009

See all articles by Stephanie J. London

Stephanie J. London

Government of the United States of America - National Institute of Environmental Health Sciences (NIEHS)

Isabelle Romieu

Government of Mexico - National Institute of Public Health

Date Written: August 6, 2009

Abstract

Marked international differences in rates of asthma and allergies and the importance of family history highlight the primacy of interactions between genetic variation and the environment in asthma etiology. Environmental tobacco smoke (or secondhand smoke), ambient air pollutants, and endotoxin and/or other pathogen-associated molecular patterns are the ambient exposures studied most frequently for interactions with genetic polymorphisms in asthma. To date, results from the literature remain inconclusive. Most published studies are underpowered to study interactions between genetic polymorphisms and ambient exposures, each with weak effects. Strategies to increase power include cooperation across studies to increase sample sizes and improve measures of both exposure and asthma phenotypes. Genome-wide association studies hold promise for identifying unexpected gene environment interactions, but given the statistical power issues, candidate gene association studies will remain important. New tools are enabling the study of epigenetic mechanisms for environmental interactions.

Keywords: genetic polymorphism endotoxin, air pollution, tobacco smoke pollution, environmental pollutants

Suggested Citation

London, Stephanie J. and Romieu, Isabelle, Gene by Environment Interaction in Asthma* (August 6, 2009). Annual Review of Public Health, Vol. 30, April 2009, Available at SSRN: https://ssrn.com/abstract=1445008

Stephanie J. London

Government of the United States of America - National Institute of Environmental Health Sciences (NIEHS) ( email )

P.O. Box 12233, Mail Drop NH 06
Changping District
Research Triangle Park, NC Changping District 27709
United States

Isabelle Romieu (Contact Author)

Government of Mexico - National Institute of Public Health ( email )

Universidad 655
Santa María Ahuacatitlán
Cuernavaca Morelos
Mexico

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