Antimalarial Drug Quality in the Most Severely Malarious Parts of Africa - A Six Country Study

PLoS ONE, Vol. 3, No. 5, pp. 1-3, 2008

3 Pages Posted: 6 Mar 2010

See all articles by Roger Bate

Roger Bate

American Enterprise Institute (AEI)

Philip Coticelli

affiliation not provided to SSRN

Richard Tren

Africa Fighting Malaria (US)

Amir Attaran

University of Ottawa - Department of Epidemiology and Community Medicine; University of Ottawa - Common Law Section

Date Written: 2008

Abstract

A range of antimalarial drugs were procured from private pharmacies in urban and peri-urban areas in the major cities of six African countries, situated in the part of that continent and the world that is most highly endemic for malaria. Semi-quantative thin-layer chromatography (TLC) and dissolution testing were used to measure active pharamceutical ingredient content against internationally acceptable standards. 35% of all samples tested failed either or both tests, and were substandard. Further, 33% of treatments collected were artemisinin monotherapies, most of which (78%) were manufactured in disobservance of an appeal by the World Health Organisation (WHO) to withdraw these clinically inappropriate medicines from the market. The high persistence of substandard drugs and clinically inappropiriate artemisinin monotherapies in the private sector risks patient safety and, through drug resistance, places the future of malaria treatment at risk globally.

Suggested Citation

Bate, Roger and Coticelli, Philip and Tren, Richard and Attaran, Amir, Antimalarial Drug Quality in the Most Severely Malarious Parts of Africa - A Six Country Study (2008). PLoS ONE, Vol. 3, No. 5, pp. 1-3, 2008, Available at SSRN: https://ssrn.com/abstract=1565618

Roger Bate

American Enterprise Institute (AEI) ( email )

1150 17th Street, N.W.
Washington, DC 20036
United States

Philip Coticelli

affiliation not provided to SSRN ( email )

Richard Tren

Africa Fighting Malaria (US) ( email )

Washington, DC
United States

Amir Attaran (Contact Author)

University of Ottawa - Department of Epidemiology and Community Medicine ( email )

451 Smyth Road
Ottawa, Ontario K1H 8M5
Canada

University of Ottawa - Common Law Section ( email )

57 Louis Pasteur Street
Ottawa, K1N 6N5
Canada
613-562-5800 ext: 2015 (Phone)
613-562-5659 (Fax)

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