Prevention of Major Depression

Posted: 4 Jun 2010  

Ricardo F. Muñoz

University of California, San Francisco (UCSF)

Pim Cuijpers

University of California, San Francisco (UCSF)

Filip Smit

VU University Amsterdam

Alinne Z. Barrera

University of California, San Francisco (UCSF)

Yan Leykin

University of California, San Francisco (UCSF)

Date Written: April 2010

Abstract

Before the 1980s, no randomized controlled trials had been carried out to test whether major depressive episodes could be prevented. In the past 30 years, several trials have reported success in reducing the incidence (the number of new cases) of major depressive episodes. These studies suggest that major depression can be prevented. Given the large burden of disease caused by major depression, it is time for substantial systematic efforts to replicate these studies, carry out multisite trials, and widely disseminate prevention interventions found to be effective. The present review examines the conceptual and practical differences between treatment and prevention trials and the importance of identifying groups at high short-term risk for major depressive episodes to make prevention trials feasible. We also list the randomized controlled prevention trials that have been carried out to date and discuss the need for prevention interventions that go beyond the limits of traditional face-to-face interventions.

Suggested Citation

Muñoz, Ricardo F., Prevention of Major Depression (April 2010). Annual Review of Clinical Psychology, Vol. 6, pp. 181-212, 2010. Available at SSRN: https://ssrn.com/abstract=1598159 or http://dx.doi.org/10.1146/annurev-clinpsy-033109-132040

Ricardo F. Muñoz (Contact Author)

University of California, San Francisco (UCSF) ( email )

Third Avenue and Parnassus
San Francisco, CA 94143
United States

Pim Cuijpers

University of California, San Francisco (UCSF) ( email )

Filip Smit

VU University Amsterdam

De Boelelaan 1105
Amsterdam, ND North Holland 1081 HV
Netherlands

Alinne Barrera

University of California, San Francisco (UCSF) ( email )

Third Avenue and Parnassus
San Francisco, CA 94143
United States

Yan Leykin

University of California, San Francisco (UCSF) ( email )

Third Avenue and Parnassus
San Francisco, CA 94143
United States

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