Genetic Interactions with Prenatal Social Environment: Effects on Academic and Behavioral Outcomes

36 Pages Posted: 4 Jun 2010 Last revised: 17 Apr 2021

See all articles by Dalton Conley

Dalton Conley

New York University (NYU) - Department of Sociology; National Bureau of Economic Research (NBER)

Emily Rauscher

affiliation not provided to SSRN

Date Written: May 2010

Abstract

Caspi et al. (2002, 2003), Guo et al. (2008a), and Pescosolido et al. (2008) all claim to have demonstrated allele-by-environment interactions, but in all cases environmental influences are potentially endogenous to the unmeasured genetic characteristics of the subjects and their families. Thus, gene-gene interactions cannot be ruled out as an alternative explanation. Second, these studies have not deployed adjustments for multiple hypothesis testing--always an issue, but particularly so for GE studies with multiple alleles and outcomes. Using data from the National Longitudinal Survey of Adolescent Health (Add Health), we address these limitations of previous studies by taking advantage of a natural experiment that randomizes a particular environmental influence - fetal position, resulting in birth weight discordance within monozygotic twin pairs (validated with dizygotic twins as well). Whether or not we use corrections for multiple statistical tests, we find no support for the GE interactions (or for main effects of genes or birth weight) found in past research and, in fact, the only significant allele-birth weight interaction we reveal works in the opposite direction of Caspi et al.'s classic finding on 5-HTT and maltreatment.

Suggested Citation

Conley, Dalton and Rauscher, Emily, Genetic Interactions with Prenatal Social Environment: Effects on Academic and Behavioral Outcomes (May 2010). NBER Working Paper No. w16026, Available at SSRN: https://ssrn.com/abstract=1612618

Dalton Conley (Contact Author)

New York University (NYU) - Department of Sociology ( email )

New York, NY 10012
United States

National Bureau of Economic Research (NBER)

1050 Massachusetts Avenue
Cambridge, MA 02138
United States

Emily Rauscher

affiliation not provided to SSRN

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