Array Comparative Genomic Hybridisation (aCGH): An Analysis of the Current Technology and Its Future in Prenatal Diagnosis

GENES, SOCIETY AND THE FUTURE, Vol. I, Part 5, Human Genome Research Project, Dunedin, NZ, 2007

27 Pages Posted: 3 May 2011

See all articles by Mildred K. Cho

Mildred K. Cho

Stanford University - Stanford Center for Biomedical Ethics (SCBE)

Mark Henaghan

University of Otago; University of Otago

Date Written: May 1, 2011

Abstract

Array comparative genomic hybridisation (aCGH) represents a major advance in the field of cytogenetics and offers tremendous promise in prenatal diagnosis for the detection of genetic alterations leading to serious genetic conditions. This technology, also sometimes known as molecular karyotyping, can detect differences in DNA copy number at hundreds or thousands of points in the genome simultaneously.

At this stage of the development of aCGH technology, a number of recommendations can be made for clinical use. These recommendations should be revisited as information about its clinical validity and utility is obtained, and as the accuracy, resolution and cost of aCGH-based tests evolve.

Keywords: Law, Genetics, Ethics, Human Genome, Genes, Array Comparative Genomic Hybridisation

Suggested Citation

Cho, Mildred K. and Henaghan, Mark, Array Comparative Genomic Hybridisation (aCGH): An Analysis of the Current Technology and Its Future in Prenatal Diagnosis (May 1, 2011). GENES, SOCIETY AND THE FUTURE, Vol. I, Part 5, Human Genome Research Project, Dunedin, NZ, 2007 . Available at SSRN: https://ssrn.com/abstract=1828473

Mildred K. Cho

Stanford University - Stanford Center for Biomedical Ethics (SCBE) ( email )

1215 Welch Road
Modular A
Stanford, CA 94305
United States

Mark Henaghan (Contact Author)

University of Otago ( email )

Faculty of Law
P.O. Box 56
Dunedin, 9054
New Zealand
64 3 479 5324 (Phone)
64 3 479 8855 (Fax)

HOME PAGE: http://otago.ac.nz/law/genome

University of Otago ( email )

PO Box 56
Dunedin North
Dunedin, 9016
New Zealand
6434798854 (Phone)
644798855 (Fax)

HOME PAGE: http://otago.ac.nz/law/genome

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