Salivary Nicotine and Cotinine Concentrations in Unstimulated and Stimulated Saliva

African Journal of Pharmacy and Pharmacology, Vol. 4, No. 2, pp. 061-065, February 2010

5 Pages Posted: 17 Mar 2012

See all articles by Noorzurani Robson

Noorzurani Robson

University of Malaya (UM)

A. Bond

affiliation not provided to SSRN

K. Wolff

affiliation not provided to SSRN

Multiple version iconThere are 2 versions of this paper

Date Written: 2010

Abstract

Salivary nicotine and salivary cotinine is widely used in clinical and epidemiological studies to validate smoking cessation. However, the reported collection for salivary nicotine and salivary cotinine vary by technique and duration. This study investigated the influence of salivary collection by unstimulation and stimulation technique of the concentration of salivary nicotine and salivary cotinine. It was found that unstimulated technique produced the highest salivary nicotine concentration, whereas stimulated technique produced the highest salivary cotinine concentration. The results of this study suggest that it is important to standardise salivary nicotine and cotinine collection technique.

Keywords: Saliva, smoker, nicotine, cotinine technique, biological marker, oral, verify, passive, tobacco, smoke flow-rate, clinical-pharmacology exposure, smoking, absorption, plasma, urine

Suggested Citation

Robson, Noorzurani and Bond, A. and Wolff, K., Salivary Nicotine and Cotinine Concentrations in Unstimulated and Stimulated Saliva (2010). African Journal of Pharmacy and Pharmacology, Vol. 4, No. 2, pp. 061-065, February 2010. Available at SSRN: https://ssrn.com/abstract=2024696

Noorzurani Robson (Contact Author)

University of Malaya (UM) ( email )

Kuala Lumpur, Wilayah Persekutuan 50603
University of Malaya (UM)
Kuala Lumpur, 50603
Malaysia

A. Bond

affiliation not provided to SSRN ( email )

K. Wolff

affiliation not provided to SSRN ( email )

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