Novel Synthesis of Bicalutamide Drug Substance and their Impurities using Imidazolium Type of Ionic Liquid

12 Pages Posted: 12 Oct 2012 Last revised: 1 Nov 2012

See all articles by M. Chand

M. Chand

affiliation not provided to SSRN

Anil Shukla

affiliation not provided to SSRN

Date Written: October 11, 2012

Abstract

The chemical and pharmaceutical industry is under an accelerating pressure to find environmentally friendly organic reaction methodologies. Owing to the unique advantages of ionic liquids, the preparation and industrial applications of ionic liquids have attracted considerable interest. Herein we report novel synthesis of imidazolium based Room-Temperature Ionic Liquid (RTIL) using cheaper reagents which have been used for the synthesis of Antiandrogenic and Antineoplastic drug Bicalutamide and its impurities reported in US pharmacopoeia.

Keywords: anti-androgen, bicalutamide, casodex, impurities, room temperature ionic liquids (RTIL)

Suggested Citation

Chand, M. and Shukla, Anil, Novel Synthesis of Bicalutamide Drug Substance and their Impurities using Imidazolium Type of Ionic Liquid (October 11, 2012). Available at SSRN: https://ssrn.com/abstract=2160199 or http://dx.doi.org/10.2139/ssrn.2160199

M. Chand

affiliation not provided to SSRN

Anil Shukla (Contact Author)

affiliation not provided to SSRN ( email )

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