A Computer Model to Analyse the Cost-Effectiveness of Hormone Replacement Therapy - a Revised Version

Posted: 5 Jun 2000

See all articles by Niklas Zethraeus

Niklas Zethraeus

Karolinska Institutet - Department of Learning, Informatics, Management and Ethics

Ragnar Lindgren

Stockholm School of Economics - Department of Finance

Olof Johnell

Lund University - University Hospital

Bengt Jonsson

Uppsala University - Department of Information Science

Abstract

This report presents a computer model for evaluating the cost-effectiveness (CE) of Hormone Replacement Therapy (HRT). The model is an extension of a previous model and includes also the risk of spine and wrist fracture. New Swedish data on risk of coronary heart disease and related mortality are included. The report describes the model's structure and data requirements; it also investigates the impact on the CE results by using the new model and by adding the wrist and spine fractures to the model. We further investigate whether the results are sensitive to the inclusion of Swedish risk and mortality data for CHD instead of using data based on the Framingham study. The results show that the incremental cost-effectiveness ratios (ICERs) are insensitive to the chosen model, to the assumption that the risk of wrist and spine fracture follows that of hip fracture, and to replacing the Framingham data with Swedish CHD risk and mortality data.

Keywords: Computer model; cost-effectiveness analysis; hormone replacement therapy

JEL Classification: D61, I10, I12, I19

Suggested Citation

Zethraeus, Niklas and Lindgren, Ragnar and Johnell, Olof and Jonsson, Bengt, A Computer Model to Analyse the Cost-Effectiveness of Hormone Replacement Therapy - a Revised Version. Available at SSRN: https://ssrn.com/abstract=223659

Niklas Zethraeus (Contact Author)

Karolinska Institutet - Department of Learning, Informatics, Management and Ethics ( email )

Tomtebodavägen 18A
SE-171 77
Stockholm
Sweden

Ragnar Lindgren

Stockholm School of Economics - Department of Finance ( email )

SE-113 83 Stockholm
Sweden
+46-8-736 91 50 (Phone)
+46-8-31 23 27 (Fax)

Olof Johnell

Lund University - University Hospital ( email )

Universitetssjukhuset MAS
205 02 Malmo
Sweden

Bengt Jonsson

Uppsala University - Department of Information Science ( email )

Box 325
S-751 05 Uppsala
SWEDEN
+46 18 4713157 (Phone)
+46 18 550225 (Fax)

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