Stochastic Model for Langerhans Cells and HIV Dynamics in Vivo
20 Pages Posted: 12 Sep 2013
Date Written: September 11, 2013
Many aspects of the complex interaction between HIV and the human immune system remain elusive. Our objective is to study these interactions, focusing on the specific roles of langerhans cells (LCs) in HIV infection. In patients infected with HIV, a large amount of virus is associated with LCs in lymphoid tissue. To assess the influence of LCs on HIV viral dynamics during anti-retroviral therapy, we present and analyse a stochastic model describing the dynamics of HIV, CD4 T-cells, and LCs interactions under therapeutic intervention in vivo. We perform sensitivity analyses on the model to determine which parameters and/or which interaction mechanisms strongly affect infection dynamics.
Keywords: HIV infection, Latent period, Langerhans cells, CD4 T-cells, Stochastic model, Therapeutic intervention
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