Reflections on the Cost of 'Low Cost' Whole Genome Sequencing: Framing the Health Policy Debate

PLOS Biology, V. 11, No. 11, November 2013, p. e1001699

U of Maryland Legal Studies Research Paper No. 2013-68

6 Pages Posted: 12 Nov 2013

See all articles by Timothy Caulfield

Timothy Caulfield

University of Alberta - Health Law Institute

James P. Evans

University of North Carolina (UNC) at Chapel Hill - School of Medicine

Amy L. McGuire

Baylor College of Medicine

Christopher McCabe

University of Alberta - Emergency Medicine

Tania Bubela

University of Alberta - Faculty of Public Health

Bob Cook-Deegan

Arizona State University (ASU) - School for the Future of Innovation in Society

Jennifer Fishman

McGill University - BioMedical Ethics Unit

Stuart Hogarth

King’s College London, Dept of Social Science, Health & Medicine

Fiona A. Miller

University of Toronto - Institute of Health Policy, Management and Evaluation

Vardit Ravitsky

University of Montreal, Dept of Social and Preventive Medicine

Barbara Biesecker

National Institutes of Health (NIH) - National Human Genome Research Institute

Pascal Borry

Catholic University of Leuven - Faculty of Medicine - Center for Biomedical Ethics and Law

Mildred K. Cho

Stanford University - Stanford Center for Biomedical Ethics (SCBE)

June Carroll

University of Toronto, Granovsky Gluskin Family Medicine Centre

Holly Etchegary

Memorial University of Newfoundland, Faculty of Medicine

Yann Joly

McGill University - Centre for Genomics and Policy

Kazuto Kato

Osaka, Dept of Biomedical Ethics & Public Policy, Graduate School of Medicine; Kyoto University, Institute for Integrated Cell-Material Sciences

Sandra Lee

Stanford University - Stanford Center for Biomedical Ethics (SCBE); Stanford University, Program in Science, Technology, and Society

Karen H. Rothenberg

University of Maryland Francis King Carey School of Law

Pamela Sankar

University of Pennsylvania - Perelman School of Medicine

Michael Szego

University of Toronto, Centre for Bioethics

Pilar Ossorio

University of Wisconsin-Madison, School of Law; Morgridge Institute for Research

Daryl Pullman

Memorial University of Newfoundland - Faculty of Medicine

Francois Rousseau

Université Laval - Faculty of Medicine

Wendy Ungar

University of Toronto - Department of Health Policy, Management and Evaluation

Brenda Wilson

University of Ottawa, Faculty of Medicine, Public Health Genomics

Date Written: November 1, 2013

Abstract

The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale and pace of adoption of this powerful new technology should be driven by clinical need, clinical evidence, and a commitment to put patients at the centre of health care policy.

Keywords: whole genome sequencing, WGS, whole exome sequencing, WES, human genome

Suggested Citation

Caulfield, Timothy and Evans, James P. and McGuire, Amy L. and McCabe, Christopher and Bubela, Tania and Cook-Deegan, Robert M and Fishman, Jennifer and Hogarth, Stuart and Miller, Fiona A. and Ravitsky, Vardit and Biesecker, Barbara and Borry, Pascal and Cho, Mildred K. and Carroll, June and Etchegary, Holly and Joly, Yann and Kato, Kazuto and Lee, Sandra and Rothenberg, Karen H. and Sankar, Pamela and Szego, Michael and Ossorio, Pilar and Pullman, Daryl and Rousseau, Francois and Ungar, Wendy and Wilson, Brenda, Reflections on the Cost of 'Low Cost' Whole Genome Sequencing: Framing the Health Policy Debate (November 1, 2013). PLOS Biology, V. 11, No. 11, November 2013, p. e1001699; U of Maryland Legal Studies Research Paper No. 2013-68. Available at SSRN: https://ssrn.com/abstract=2351458

Timothy Caulfield (Contact Author)

University of Alberta - Health Law Institute ( email )

Law Centre
Edmonton, Alberta T6G 2H5
Canada

James P. Evans

University of North Carolina (UNC) at Chapel Hill - School of Medicine ( email )

Amy L. McGuire

Baylor College of Medicine ( email )

One Baylor Plaza
Apt 510
Houston, TX TX - Texas 77030
United States

Christopher McCabe

University of Alberta - Emergency Medicine ( email )

116 St. and 85 Ave
Edmonton, Alberta T6G 2R3
Canada
(780) 492-4202 (Phone)

Tania Bubela

University of Alberta - Faculty of Public Health ( email )

11405 - 87 Ave.
Edmonton, Alberta T6G 1C9
Canada
(780) 492-9335 (Phone)

Robert M Cook-Deegan

Arizona State University (ASU) - School for the Future of Innovation in Society ( email )

PO Box 875603
Tempe, AZ 85287-560
United States

Jennifer Fishman

McGill University - BioMedical Ethics Unit ( email )

3647 Peel Street
Montreal, Quebec H3A 1X1
Canada
514-398-6980 (Phone)

Stuart Hogarth

King’s College London, Dept of Social Science, Health & Medicine ( email )

London, SE1 9NN
United Kingdom

Fiona A. Miller

University of Toronto - Institute of Health Policy, Management and Evaluation ( email )

155 College Street
Suite 425
Toronto, Ontario M5T 3M6
Canada
416 978-3703 (Phone)

Vardit Ravitsky

University of Montreal, Dept of Social and Preventive Medicine ( email )

C.P. 6128 succursale Centre-ville
Montreal, Quebec H3C 3J7
Canada

Barbara Biesecker

National Institutes of Health (NIH) - National Human Genome Research Institute ( email )

Building 31, Room B1B36
31 Center Dr, MSC 2073
Bethesda, MD 20892
United States
(301) 496-3979 (Phone)
(301) 480-3108 (Fax)

HOME PAGE: http://www.genome.gov/10001536

Pascal Borry

Catholic University of Leuven - Faculty of Medicine - Center for Biomedical Ethics and Law ( email )

Oude Markt 13
Leuven, Vlaams-Brabant
Belgium

Mildred K. Cho

Stanford University - Stanford Center for Biomedical Ethics (SCBE) ( email )

1215 Welch Road
Modular A
Stanford, CA 94305
United States

June Carroll

University of Toronto, Granovsky Gluskin Family Medicine Centre ( email )

60 Murray St. 4th Floor, Box 25
Toronto, Ontario ON M5T 3L9
Canada
416 586-4800 x 5158 (Phone)

HOME PAGE: http://www.dfcm.utoronto.ca/research/researchers/jcarroll.htm

Holly Etchegary

Memorial University of Newfoundland, Faculty of Medicine

Faculty of Medicine
St. John's, Newfoundland A1B 3X5 A1C 5V3
Canada

Yann Joly

McGill University - Centre for Genomics and Policy ( email )

740 Dr. Penfield Avenue, Suite 5200
Montreal, Quebec H3A 0G1
Canada

Kazuto Kato

Osaka, Dept of Biomedical Ethics & Public Policy, Graduate School of Medicine

1-3 Machikaneyama-cho, Toyonaka
Osaka, 560-8531
Japan

Kyoto University, Institute for Integrated Cell-Material Sciences

Yoshida-Honmachi
Sakyo-ku
Kyoto, 606-8501
Japan

Sandra Lee

Stanford University - Stanford Center for Biomedical Ethics (SCBE) ( email )

CA
United States

Stanford University, Program in Science, Technology, and Society

Stanford, CA 94305
United States

Karen H. Rothenberg

University of Maryland Francis King Carey School of Law ( email )

500 West Baltimore Street
Baltimore, MD 21201-1786
United States

Pamela Sankar

University of Pennsylvania - Perelman School of Medicine ( email )

423 Guardian Drive
Philadelphia, PA 19104
United States

Michael Szego

University of Toronto, Centre for Bioethics ( email )

Toronto, Ontario M5S 3G8
Canada

Pilar Ossorio

University of Wisconsin-Madison, School of Law; Morgridge Institute for Research ( email )

716 Langdon Street
Madison, WI 53706-1481
United States

Daryl Pullman

Memorial University of Newfoundland - Faculty of Medicine ( email )

Faculty of Education
St. John's, Newfoundland A1B 3X5 A1C 5V3
Canada

Francois Rousseau

Université Laval - Faculty of Medicine

2214 Pavillon J-A. DeSeve
Quebec G1K 7P4
Canada

Wendy Ungar

University of Toronto - Department of Health Policy, Management and Evaluation ( email )

Toronto
Canada

Brenda Wilson

University of Ottawa, Faculty of Medicine, Public Health Genomics ( email )

2292 Edwin Crescent
Ottawa, Ontario K2C 1H7
Canada

Register to save articles to
your library

Register

Paper statistics

Downloads
34
Abstract Views
987
PlumX Metrics