A Parallel Functional Topography between Medial and Lateral Prefrontal Cortex: Evidence and Implications for Cognitive Control

The Journal of Neuroscience, March 30, 2011 • 31(13):5026 –5031

Fox School of Business Research Paper

6 Pages Posted: 28 Apr 2014 Last revised: 31 Dec 2016

See all articles by Adrienne Taren

Adrienne Taren

Duke University - Department of Psychology and Neuroscience

Vinod Venkatraman

Temple University - Department of Marketing and Supply Chain Management

Scott Huettel

Duke University - Department of Psychology and Neuroscience

Date Written: November 2, 2010

Abstract

The dorsomedial and dorsolateral prefrontal cortices (dmPFC and dlPFC) together support cognitive control, with dmPFC responsible for monitoring performance and dlPFC responsible for adjusting behavior. The dlPFC contains a topographic organization that reflects complexity of control demands, with more anterior regions guiding increasingly abstract processing. Recent evidence for a similar gradient within dmPFC suggests the possibility of parallel, hierarchical organization. Here, we measured connectivity between functional nodes of dmPFC and dlPFC using resting-state functional magnetic resonance imaging in humans. We found a posterior-to-anterior connectivity gradient; posterior dmPFC maximally connected to posterior dlPFC and anterior dmPFC maximally connected to anterior dlPFC. This parallel topographic pattern replicated across three independent datasets collected on different scanners, within individual participants, and through both point-to-point and voxelwise analyses. We posit a model of cognitive control characterized by hierarchical interactions — whose level depends on current environmental demands — between functional subdivisions of medial and lateral PFC.

Suggested Citation

Taren, Adrienne and Venkatraman, Vinod and Huettel, Scott, A Parallel Functional Topography between Medial and Lateral Prefrontal Cortex: Evidence and Implications for Cognitive Control (November 2, 2010). The Journal of Neuroscience, March 30, 2011 • 31(13):5026 –5031, Fox School of Business Research Paper, Available at SSRN: https://ssrn.com/abstract=2430384

Adrienne Taren

Duke University - Department of Psychology and Neuroscience ( email )

Durham, NC 27708
United States

Vinod Venkatraman (Contact Author)

Temple University - Department of Marketing and Supply Chain Management ( email )

Philadelphia, PA 19122
United States

Scott Huettel

Duke University - Department of Psychology and Neuroscience ( email )

Durham, NC 27708
United States

Do you have a job opening that you would like to promote on SSRN?

Paper statistics

Downloads
14
Abstract Views
393
PlumX Metrics