Sleep Deprivation Elevates Expectation of Gains and Attenuates Response to Losses Following Risky Decisions

SLEEP, Vol. 30, No. 5, 2007

7 Pages Posted: 2 May 2014 Last revised: 31 Dec 2016

See all articles by Vinod Venkatraman

Vinod Venkatraman

Temple University - Department of Marketing and Supply Chain Management

Lisa Chuah

Singapore Health Services Pte Ltd

Scott Huettel

Duke University - Department of Psychology and Neuroscience

Michael Chee

Duke-NUS Graduate Medical School Singapore

Date Written: September 1, 2006

Abstract

Study Objectives: Using a gambling task, we investigated how 24 hours of sleep deprivation modulates the neural response to the making of risky decisions with potentially loss-bearing outcomes.

Design: Two experiments involving sleep-deprived subjects were performed. In the first, neural responses to decision making and reward outcome were evaluated. A second control experiment evaluated responses to reward outcome only.

Participants: Healthy right-handed adults participated in these experiments (26 [mean age 21.3 years] in Experiment 1 and 13 [mean age 21.7 years] in Experiment 2.)

Measurements and Results: Following sleep deprivation, choices involving higher relative risk elicited greater activation in the right nucleus accumbens, signifying an elevated expectation of the higher reward once the riskier choice was made. Concurrently, activation for losses in the insular and orbitofrontal cortices was reduced, denoting a diminished response to losses. This latter finding of reduced insular activation to losses was also true when volunteers were merely shown the results of the computer’s decision, that is, without having to make their own choice. Conclusions: These results suggest that sleep deprivation poses a dual threat to competent decision making by modulating activation in nucleus accumbens and insula, brain regions associated with risky decision making and emotional processing.

Keywords: functional neuroimaging, risk taking, decision making, nucleus accumbens, orbitofrontal cortex

Suggested Citation

Venkatraman, Vinod and Chuah, Lisa and Huettel, Scott and Chee, Michael, Sleep Deprivation Elevates Expectation of Gains and Attenuates Response to Losses Following Risky Decisions (September 1, 2006). SLEEP, Vol. 30, No. 5, 2007, Available at SSRN: https://ssrn.com/abstract=2430748

Vinod Venkatraman (Contact Author)

Temple University - Department of Marketing and Supply Chain Management ( email )

Philadelphia, PA 19122
United States

Lisa Chuah

Singapore Health Services Pte Ltd ( email )

7 Hospital Drive
Block A, Room #02-01
Singapore, 597627
Singapore

Scott Huettel

Duke University - Department of Psychology and Neuroscience ( email )

Durham, NC 27708
United States

Michael Chee

Duke-NUS Graduate Medical School Singapore ( email )

Singapore
Singapore

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