Bioconversion of L-Tyrosine to L-Dopa By Novel Bacterium Bacillus Cereus Isolated from Wadala Region
Indian Streams Research Journal, Volume-4, Issue-8, Sept-2014
10 Pages Posted: 15 Sep 2014
Date Written: September 1, 2014
L-DOPA (L-3, 4-dihydroxyphenylalanine) is an amino acid derivative and most portent drug used against Parkinson’s disease, crosses the protective blood–brain barrier, whereas dopamine itself cannot. Thus, L-DOPAis used to increase dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia. In present communication, we have studied the in vitro production of L-DOPA from L-tyrosine by bacterium Bacillus cereus. This bacterium produced L-DOPA from L-tyrosine in buffer (pH 8) containing 1mg/ml cell mass incubated at 40°c for 60min. This is the first report on rapid and efficient production of L-DOAP from L-tyrosine by bacterial source which is more effective than plant, fungal and other systems. L-tyrosine is also used in cosmetics and some pharmaceutical products.
Keywords: L-DOPA((L-3, 4-dihydroxyphenylalanine)), L-tyrosine, Bacillus cereus
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