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Practical Research Designs for Investigating Modes of HIV Transmission

Presented at the 11th Annual Meeting of the Safe Injection Global Network, Dubai, 9-11 Nov 2010.

13 Pages Posted: 26 Dec 2014  

Devon D. Brewer

Interdisciplinary Scientific Research

Date Written: November 9, 2010

Abstract

Despite 30 years of epidemiologic research on HIV transmission, no published investigations in sub-Saharan Africa or Asia have involved study designs that allow HIV transmission modes to be determined with confidence. Consequently, there is much uncertainty about what is driving HIV transmission in these regions, which hampers prevention. There are four design elements in a rigorous investigation: inclusion of persons with incident HIV infection (cases) and uninfected controls, comprehensive assessment of blood and sexual exposures, tracing of contacts to such exposures for both cases and controls, and sequencing of infected persons' HIV DNA to identify persons with genetically related infections. Although all four elements are necessary to determine transmission modes with greatest confidence, investigations with the first two or three elements provide stronger evidence than exists currently and offer useful guidance on prevention strategies until more definitive investigations can be conducted. Investigations with these design elements can piggyback on existing clinical and other health services, and thus require little or no funding to implement. Scientific help is available for conducting these investigations. The most important requirement for starting this kind of project is the desire to know what is driving HIV transmission in one’s community.

Keywords: infectious disease, research methods, research design, epidemiology

JEL Classification: C90, I18

Suggested Citation

Brewer, Devon D., Practical Research Designs for Investigating Modes of HIV Transmission (November 9, 2010). Presented at the 11th Annual Meeting of the Safe Injection Global Network, Dubai, 9-11 Nov 2010.. Available at SSRN: https://ssrn.com/abstract=2542630 or http://dx.doi.org/10.2139/ssrn.2542630

Devon D. Brewer (Contact Author)

Interdisciplinary Scientific Research ( email )

P.O. Box 15110
Seattle, WA 98115
United States
206-985-2398 (Phone)
815-301-8854 (Fax)

HOME PAGE: http://www.interscientific.net

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