The Role of Whole Genome and Whole Exome Sequencing in Preventive Genomic Sequencing Programs

The American Journal of Bioethics, 15:7, 22-24

4 Pages Posted: 7 Aug 2015

See all articles by Gabrielle Bertier

Gabrielle Bertier

McGill University

Ma'n H. Zawati

McGill University - Centre of Genomics and Policy

Yann Joly

McGill University - Centre for Genomics and Policy

Date Written: July 6, 2015

Abstract

The target article by Lázaro-Muñoz and colleagues (2015) proposes policy recommendations on opt-in/opt-out strategies for the development of population-based preventive genomic sequencing programs (PGSP). Through a rather summary analysis, the authors ground their recommendation for “menu”- rather than “panel”-based PGSPs on a number of technical, public health, legal and ethical considerations. The main challenges identified in the article, such as the complex issue of whether a PGSP’s objective is to promote public or individual health, and the difficulty of communicating genetic sequencing risks and benefits to participants, are highly relevant. However, we argue that it is necessary to take into account recent advances in the field of next generation sequencing, and to focus on the existing data as well as the few rare yet high-profile incidents of genetic discrimination, before one can make strong policy recommendations for PGSP design.

Keywords: Role, Whole Exome Sequencing, Whole Genome Sequencing, Preventive Genomic Sequencing, Programs, Population-based, Technical, Public health, Legal and Ethical considerations, Risks, Benefits, Genetic Discrimination

Suggested Citation

Bertier, Gabrielle and Zawati, Ma'n H. and Joly, Yann, The Role of Whole Genome and Whole Exome Sequencing in Preventive Genomic Sequencing Programs (July 6, 2015). The American Journal of Bioethics, 15:7, 22-24, Available at SSRN: https://ssrn.com/abstract=2640215

Gabrielle Bertier

McGill University ( email )

1001 Sherbrooke St. W
Montreal, Quebec H3A 1G5
Canada

Ma'n H. Zawati (Contact Author)

McGill University - Centre of Genomics and Policy ( email )

740 Dr. Penfield Avenue, Suite 5200
Montreal, Quebec H3A 0G1
Canada

Yann Joly

McGill University - Centre for Genomics and Policy ( email )

740 Dr. Penfield Avenue, Suite 5200
Montreal, Quebec H3A 0G1
Canada

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