Effect of Milrinone on Short Term Outcome of Patients with Myocardial Dysfunction Undergoing Off-Pump Coronary Artery Bypass Graft: A Randomized Clinical Trial

Acta Medica Iranica, 2013

6 Pages Posted: 11 Sep 2015

See all articles by Mehdi Hadadzadeh

Mehdi Hadadzadeh

Shahid Sadoughi University of Medical Sciences

Seyed Habib Hosseini

Shahid Sadoughi University of Medical Sciences

Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada

Nafiseh Naderi

McGill University - Division of Experimental Medicine; Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada

Mahmood Emami-Meybodi

Shahid Sadoughi University of Medical Sciences

Date Written: 2013

Abstract

Myocardial dysfunction is a major complication in cardiac surgery that needs inotropic support. This study evaluates the effect of milrinone on patients with low ventricular ejection fraction undergoing offpump coronary artery bypass graft (OPCAB). The present study is designed to evaluate the effect of milrinone on myocardial dysfunction. Eighty patients with low ventricular ejection fraction (<35%), candidate for elective OPCAB, were enrolled in this study. They were randomly assigned to two groups. One group received milrinone (50 μg/kg) intravenously and another group received a saline as placebo followed by 24 hours infusion of each agent (0.5 μg/kg/min). Short outcome of patients such as hemodynamic parameters and left ventricular ejection fraction were variables evaluated. Serum levels of creatine phosphokinase, the MB isoenzyme of creatine kinase, occurrence of arrhythmias and mean duration of mechanical ventilation were significantly lower in milrinone group (P<0.05). The mean post operative left ventricular ejection fraction was significantly higher in milrinone group (P=0.031). There were no statistical significant differences between the two groups in terms of intra-aortic balloon pump, inotropic support requirement, myocardial ischemia, myocardial infarction, duration of inotropic support, duration of intensive care unit stay, mortality and morbidity rate. Administration of milrinone in patients undergoing OPCAB with low ventricular ejection fraction is useful and effective.

Keywords: Low ventricular ejection fraction; Milrinone; Myocardial dysfunction; Off-pump coronary artery bypass graft

Suggested Citation

Hadadzadeh, Mehdi and Hosseini, Seyed Habib and Mostafavi-Pour-Manshadi, Seyed-Mohammad-Yousof and Naderi, Nafiseh and Emami-Meybodi, Mahmood, Effect of Milrinone on Short Term Outcome of Patients with Myocardial Dysfunction Undergoing Off-Pump Coronary Artery Bypass Graft: A Randomized Clinical Trial (2013). Acta Medica Iranica, 2013. Available at SSRN: https://ssrn.com/abstract=2658395

Mehdi Hadadzadeh

Shahid Sadoughi University of Medical Sciences ( email )

Shohaday-e-Gomnam Blvd.
Alem Sq.
Yazd
Iran

Seyed Habib Hosseini

Shahid Sadoughi University of Medical Sciences ( email )

Shohaday-e-Gomnam Blvd.
Alem Sq.
Yazd
Iran

Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi (Contact Author)

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada ( email )

Montreal, Quebec
Canada

Nafiseh Naderi

McGill University - Division of Experimental Medicine ( email )

Montreal, Quebec
Canada

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada ( email )

Mahmood Emami-Meybodi

Shahid Sadoughi University of Medical Sciences ( email )

Shohaday-e-Gomnam Blvd.
Alem Sq.
Yazd
Iran

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