Bortezomib in Anti-Cancer Activity: A Potential Drug

Global Journal of Cancer Therapy, Vol. 2(1), March 2016

4 Pages Posted: 12 Jul 2017

See all articles by Rajagopal Appavu

Rajagopal Appavu

Indian Institute of Science (IISc); University of Texas Medical Branch-Galveston; University of Texas at Houston - MD Anderson Cancer Center

Deepa Mohan

Independent

Date Written: March 8, 2016

Abstract

26S proteasome is an intracellular; ATP dependent enzymatic complex degrades ubiquitin-tagged proteins and maintains cellular homeostasis. The orderly degraded proteins including cyclins, caspases, Bcl-xL, p53, cell adhesion molecules are involved in cell-cycle progression, tumor suppression, DNA replication, inflammation, and apoptosis. So, proteasome inhibition is a target therapy for cancer to promote cell cycle arrest or apoptosis. Bortezomib (VelcadeĀ®, PS-341, and Millennium Pharmaceuticals, Inc.) is the first, selective, reversible, and only proteasome inhibitor for the treatment of multiple myeloma have been approved by U.S. Food and Drug Administration (FDA) in 2003. Bortezomib downregulates the interaction of multiple myeloma cells with bone marrow stromal cells, inhibits angiogenesis, and blocks cell cycle progression. Clinically, continuous dosage of bortezomib leads to few side effects.

Keywords: 26S Proteasome, Multiple Myeloma, Bortezomib, Inhibition of Transcriptional Factors, Apoptosis

Suggested Citation

Appavu, Rajagopal and Mohan, Deepa, Bortezomib in Anti-Cancer Activity: A Potential Drug (March 8, 2016). Global Journal of Cancer Therapy, Vol. 2(1), March 2016. Available at SSRN: https://ssrn.com/abstract=2755291

Rajagopal Appavu (Contact Author)

Indian Institute of Science (IISc) ( email )

Bangalore, IN Karnataka 560012
India

University of Texas Medical Branch-Galveston ( email )

Galveston, TX 77555
United States

University of Texas at Houston - MD Anderson Cancer Center ( email )

1515 Holcombe Blvd
Houston, TX 77230-1402
United States

Deepa Mohan

Independent ( email )

No Address Available

Here is the Coronavirus
related research on SSRN

Paper statistics

Downloads
22
Abstract Views
167
PlumX Metrics