Mathematical Formulas for Prion All Cross-Structures Listed in the Protein Data Bank

Zhang J (2016) Mathematical Formulas for Prion All Cross-Structures Listed in the Protein Data Bank. Med chem (Los Angeles) 6:179-188. doi:10.4172/2161-0444.1000343

10 Pages Posted: 10 Jul 2017

See all articles by Jiapu Zhang

Jiapu Zhang

Swinburne University of Technology

Date Written: March 31, 2016

Abstract

Prion protein (PrP) has two regions:unstructured region PrP(1-120) and structured region PrP(119-231). In the structured region, there are many segments which have the property of amyloid fibril formation. By theoretical calculations, PrP(126-133), PrP(137-143), PrP(170-175), PrP(177-182), PrP(211-216) have the amyloid fibril forming property. PrP(142-166) has a X-ray crystallography experimentalβ-hairpin structure, instead of a pure cross-βamyloid fibril structure; thus we cannot clearly find it by our theoretical calculations. However,we can predict that there must be a laboratory X-ray crystal structure in PrP(184-192) segment that will be produced in the near future. The experiments of X-ray crystallography laboratories are agreeing with our theoretical calculations. This article summarized mathematical formulas of prion amyloid fibril cross-β structures of all the above PrP segments currently listed in the Protein Data Bank.Key words: PrP structured region; amyloid fibril formation peptides; theoretical calculations; experimental laboratories; mathematical formulasThe Medicinal Chemistryjournal: submitted on Feb-20-2016, revisedon Mar-29-2016, acceptedon Apr-04-2016Table 1 lists the cross-βstructures of all PrP segments that were listed in the Protein Data Bank (PDB, www.rcsb.org), produced by X-ray crystallography experiments. In the below, 01~24give some mathematical formulas to describe all these cross-βstructures.

Keywords: PrP structured region; Amyloid fibril formation peptides; Theoretical calculations; Experimental laboratories; Mathematical formulas

Suggested Citation

Zhang, Jiapu, Mathematical Formulas for Prion All Cross-Structures Listed in the Protein Data Bank (March 31, 2016). Zhang J (2016) Mathematical Formulas for Prion All Cross-Structures Listed in the Protein Data Bank. Med chem (Los Angeles) 6:179-188. doi:10.4172/2161-0444.1000343. Available at SSRN: https://ssrn.com/abstract=2763804 or http://dx.doi.org/10.2139/ssrn.2763804

Jiapu Zhang (Contact Author)

Swinburne University of Technology ( email )

Cnr Wakefield and William Streets, Hawthorn Victor
3122 Victoria, Victoria 3122
Australia

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