Problem-Driven Innovation in Drug Discovery: Co-Evolution of the Patterns of Radical Innovation with the Evolution of Problems

Problem-driveninnovationsindrugdiscovery: Co-evolution of the patterns of radical innovation with the evolution of problems, doi.org/10.1016/j.hlpt.2016.02.003

Posted: 16 Jul 2016

See all articles by Mario Coccia

Mario Coccia

National Research Council of Italy (CNR)

Date Written: July 15, 2016

Abstract

A fundamental problem in the field of the product innovation management in biopharmaceutical industry is how to explain the general source of drug discovery and radical innovations that sustain the competitive advantage of firms and technological progress in medicine. The current study confronts this problem by developing a conceptual framework of problem-driven innovation. The inductive study, based on ground-breaking drugs for lung cancer treatment, shows de facto that the perception and solution of problem is an invariant force that supports source of radical innovation and evolution of new technology. This evolution of radical innovations, driven by the evolution of problems, generates a major technological change in medicine. This finding, in a Schumpeterian world of innovation-based competition, is due to the organizational behaviour of leading firms that have a strong incentive to find innovative solutions to unsolved problems in order to achieve the prospect of a (temporary) profit monopoly. The vital linkages between observed facts support a theoretical framework of the source and evolution of path-breaking innovations in medicine, which can be generalized to explain the long-term technological change in society. The finding here is also important to design data-sharing health policy in order to promote innovation for better therapies and an efficient “healthcare ecosystem”.

Keywords: Product Innovation Management, Cancer, Technological Paradigm, Target Therapy, Radical Innovation, Commons, Problem Solving, Data Sharing, Drug Discovery, Eco-system, Health Policy

JEL Classification: O32, O33

Suggested Citation

Coccia, Mario, Problem-Driven Innovation in Drug Discovery: Co-Evolution of the Patterns of Radical Innovation with the Evolution of Problems (July 15, 2016). Problem-driveninnovationsindrugdiscovery: Co-evolution of the patterns of radical innovation with the evolution of problems, doi.org/10.1016/j.hlpt.2016.02.003 , Available at SSRN: https://ssrn.com/abstract=2810128

Mario Coccia (Contact Author)

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