Return of Genetic Testing Results in the Era of Whole-Genome Sequencing

Nature Reviews Genetics 16, 553-559 (September 2015)

7 Pages Posted: 22 Sep 2016 Last revised: 3 Apr 2018

See all articles by Bartha Knoppers

Bartha Knoppers

McGill University - Centre for Genomics and Policy

Ma'n H. Zawati

McGill University - Centre of Genomics and Policy

Karine Sénécal

McGill University - Centre for Genomics and Policy

Date Written: August 4, 2015

Abstract

Genetic testing based on whole-genome sequencing (WGS) often returns results that are not directly clinically actionable as well as raising the possibility of incidental (secondary) findings. In this article, we first survey the laws and policies guiding both researchers and clinicians in the return of results for WGS-based genetic testing. We then provide an overview of the landscape of international legislation and policies for return of these results, including considerations for return of incidental findings. Finally, we consider a range of approaches for the return of results.

Keywords: Genetic Services, Genetic Testing

Suggested Citation

Knoppers, Bartha and Zawati, Ma'n H. and Sénécal, Karine, Return of Genetic Testing Results in the Era of Whole-Genome Sequencing (August 4, 2015). Nature Reviews Genetics 16, 553-559 (September 2015), Available at SSRN: https://ssrn.com/abstract=2839918

Bartha Knoppers

McGill University - Centre for Genomics and Policy ( email )

740 Dr. Penfield Avenue, Suite 5200
Montreal, Quebec H3A 0G1
Canada

Ma'n H. Zawati (Contact Author)

McGill University - Centre of Genomics and Policy ( email )

740 Dr. Penfield Avenue, Suite 5200
Montreal, Quebec H3A 0G1
Canada

Karine Sénécal

McGill University - Centre for Genomics and Policy ( email )

740 Dr. Penfield Avenue, Suite 5200
Montreal, Quebec H3A 0G1
Canada

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