Streamlining Review of Research Involving Humans: Canadian Models

J Med Genet 2015;52:566-569

5 Pages Posted: 22 Sep 2016 Last revised: 3 Apr 2018

See all articles by Ma'n H. Zawati

Ma'n H. Zawati

McGill University - Centre of Genomics and Policy

Anne Junker

Independent

Bartha Knoppers

McGill University - Centre for Genomics and Policy

Vasiliki Rahimzadeh

Independent

Date Written: June 3, 2015

Abstract

Biomedical research post sequencing of the first human genome is increasingly eroding a traditional ecology of individualist science. It is, furthermore, normalising collective innovation and shared scientific discovery. Achieving sound statistical power in a genome-wide association study, for example, can often be well beyond the scope of any one researcher’s capacity. For this reason and others, the scientific imperative of research collaboration can be more pronounced in the ‘omics’ disciplines, where millions of data points are needed to make global inferences about links between the human genome and disease. From the scientific necessity to adequately power a study through research collaborations is also born an ethical imperative to do so. That is, the anticipated benefits and harms of a particular study are justified based on the researchers’ sound predictions about potential outcomes and contributions to knowledge. Either underestimating or overestimating translational possibilities can disturb the benefit–harm balance due largely to insufficient statistical power.

Suggested Citation

Zawati, Ma'n H. and Junker, Anne and Knoppers, Bartha and Rahimzadeh, Vasiliki, Streamlining Review of Research Involving Humans: Canadian Models (June 3, 2015). J Med Genet 2015;52:566-569, Available at SSRN: https://ssrn.com/abstract=2839920

Ma'n H. Zawati (Contact Author)

McGill University - Centre of Genomics and Policy ( email )

740 Dr. Penfield Avenue, Suite 5200
Montreal, Quebec H3A 0G1
Canada

Anne Junker

Independent ( email )

Bartha Knoppers

McGill University - Centre for Genomics and Policy ( email )

740 Dr. Penfield Avenue, Suite 5200
Montreal, Quebec H3A 0G1
Canada

Vasiliki Rahimzadeh

Independent ( email )

Do you have a job opening that you would like to promote on SSRN?

Paper statistics

Downloads
4
Abstract Views
262
PlumX Metrics