An Overview of Mice Models: A Key for Understanding Subtypes of Mania

International Journal of Psychological Research, Vol. 9 (Special Issue): p. 113-123, 2016

10 Pages Posted: 1 Dec 2016

See all articles by Jorge Mauricio Cuartas Arias

Jorge Mauricio Cuartas Arias

Universidad de San Buenaventura - Medellín - Grupo de salud comportamental y organizacional

Ana Díaz Zuluaga

Universidad de Antioquia - Grupo de investigación en psiquiatría (GIPSI)

Carlos Jaramillo

Universidad de Antioquia - Grupo de investigación en psiquiatría (GIPSI)

Date Written: November 29, 2016

Abstract

Animal models have been broadly used in the study of pathophysiology and molecular and neurochemical pathways in neuropsychiatric diseases. Different approaches have used both consanguineous and non-consanguineous mice models to model behavioral patterns associated with the maniac spectrum. However, the disadvantages of validating clinical and experimental protocols have hindered the replication of these studies. In this article, the advantages and disadvantages of using consanguineous lines and non-consanguineous stocks in mice animal models for the study of mania and its subtypes are discussed. Additionally, new experimental alternatives to advance the pathogenesis and pharmacogenetics of mania using animal models are proposed and analyzed.

Keywords: Animal Models, Bipolar Disorder, Knockout and Mania

Suggested Citation

Cuartas Arias, Jorge Mauricio and Díaz Zuluaga, Ana and Jaramillo, Carlos, An Overview of Mice Models: A Key for Understanding Subtypes of Mania (November 29, 2016). International Journal of Psychological Research, Vol. 9 (Special Issue): p. 113-123, 2016 , Available at SSRN: https://ssrn.com/abstract=2877281

Jorge Mauricio Cuartas Arias (Contact Author)

Universidad de San Buenaventura - Medellín - Grupo de salud comportamental y organizacional ( email )

Medellín
Colombia

Ana Díaz Zuluaga

Universidad de Antioquia - Grupo de investigación en psiquiatría (GIPSI)

Medellín
Colombia

Carlos Jaramillo

Universidad de Antioquia - Grupo de investigación en psiquiatría (GIPSI) ( email )

Medellín
Colombia

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