Dissociable Frontostriatal White Matter Connectivity Underlies Reward and Motor Impulsivity

Posted: 15 Feb 2017 Last revised: 15 Mar 2017

See all articles by William Hampton

William Hampton

Temple University - Department of Psychology; Decision Neuroscience

Kylie Alm

Temple University - Department of Psychology

Vinod Venkatraman

Temple University - Department of Marketing and Supply Chain Management

Ingrid Olson

Temple University - Department of Psychology

Date Written: 2016

Abstract

Dysfunction of cognitive control often leads to impulsive decision-making in clinical and healthy populations. Some research suggests that a generalized cognitive control mechanism underlies the ability to modulate various types of impulsive behavior, while other evidence suggests different forms of impulsivity are dissociable, and rely on distinct neural circuitry. Past research consistently implicates several brain regions, such as the striatum and portions of the prefrontal cortex, in impulsive behavior. However the ventral and dorsal striatum are distinct in regards to function and connectivity. Nascent evidence points to the importance of frontostriatal white matter connectivity in impulsivity, yet it remains unclear whether particular tracts relate to different control behaviors. Here we used probabilistic tractography of diffusion imaging data to relate ventral and dorsal frontostriatal connectivity to reward and motor impulsivity measures. We found a double dissociation such that individual differences in white matter connectivity between the ventral striatum and the ventromedial prefrontal cortex and dorsolateral prefrontal cortex was associated with reward impulsivity, as measured by delay discounting, whereas connectivity between dorsal striatum and supplementary motor area was associated with motor impulsivity, but not vice versa. Our findings suggest that (a) structural connectivity can is associated with a large amount of behavioral variation; (b) different types of impulsivity are driven by dissociable frontostriatal neural circuitry.

Keywords: decision making, impulsivity, reward, ventral striatum, white matter introduction

JEL Classification: D87,D90

Suggested Citation

Hampton, William and Alm, Kylie and Venkatraman, Vinod and Olson, Ingrid, Dissociable Frontostriatal White Matter Connectivity Underlies Reward and Motor Impulsivity (2016). Fox School of Business Research Paper No. 17-005, Available at SSRN: https://ssrn.com/abstract=2917050

William Hampton (Contact Author)

Temple University - Department of Psychology ( email )

Weiss Hall
1701 N. 13th St.
Philadelphia, PA 19122
United States

Decision Neuroscience ( email )

Philadelphia, PA 19122
United States

Kylie Alm

Temple University - Department of Psychology ( email )

Weiss Hall
1701 N. 13th St.
Philadelphia, PA 19122
United States

Vinod Venkatraman

Temple University - Department of Marketing and Supply Chain Management ( email )

Philadelphia, PA 19122
United States

Ingrid Olson

Temple University - Department of Psychology ( email )

Philadelphia, PA 19122
United States

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