Extraction of Bioactives from Orthosiphon Stamineus Using Microwave and Ultrasound-Assisted Techniques: Process Optimization and Scale Up

Food Chemistry, Vol. 221, p. 1382-1387, 2017

18 Pages Posted: 14 Mar 2017

See all articles by Chung-Hung Chan

Chung-Hung Chan

affiliation not provided to SSRN

Tiam You See

University of Malaya (UM) - Department of Chemical Engineering

Rozita Yusoff

University of Malaya (UM) - Department of Chemistry

Gek-Cheng Ngoh

University of Malaya (UM) - Department of Chemistry

Kien Woh Kow

UCSI University

Date Written: February 22, 2017

Abstract

This work demonstrated the optimization and scale up of microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE) of bioactive compounds from Orthosiphon stamineus using energy-based parameters such as absorbed power density and absorbed energy density (APD-AED) and response surface methodology (RSM). The intensive optimum conditions of MAE obtained at 80% EtOH, 50 mL/g, APD of 0.35W/mL, AED of 250 J/mL can be used to determine the optimum conditions of the scale-dependent parameters i.e. microwave power and treatment time at various extraction scales (100-300 mL solvent loading). The yields of the up scaled conditions were consistent with less than 8% discrepancy and they were about 91-98% of the Soxhlet extraction yield. By adapting APD-AED method in the case of UAE, the intensive optimum conditions of the extraction, i.e. 70% EtOH, 30 mL/g, APD of 0.22 W/mL, AED of 450 J/mL are able to achieve similar scale up results.

Keywords: Microwave Extraction, Ultrasonic Extraction, Bioactive Compounds, Orthosiphon Stamineus, Scale Up

JEL Classification: C61, A00, B00, C90, I20, Q20, Q00, Q16, Q32

Suggested Citation

Chan, Chung-Hung and See, Tiam You and Yusoff, Rozita and Ngoh, Gek-Cheng and Kow, Kien Woh, Extraction of Bioactives from Orthosiphon Stamineus Using Microwave and Ultrasound-Assisted Techniques: Process Optimization and Scale Up (February 22, 2017). Food Chemistry, Vol. 221, p. 1382-1387, 2017, Available at SSRN: https://ssrn.com/abstract=2921736

Chung-Hung Chan (Contact Author)

affiliation not provided to SSRN

Tiam You See

University of Malaya (UM) - Department of Chemical Engineering ( email )

Centre for Separation Science and Technology,
Faculty of Engineering
Kuala Lumpur, 50603
Malaysia

Rozita Yusoff

University of Malaya (UM) - Department of Chemistry

Jalan Lembah Pantai
Kuala Lumpur, Wilayah Persekutuan 50603
Malaysia

Gek-Cheng Ngoh

University of Malaya (UM) - Department of Chemistry

Jalan Lembah Pantai
Kuala Lumpur, Wilayah Persekutuan 50603
Malaysia

Kien Woh Kow

UCSI University ( email )

No. 1, Jalan Menara Gading,
UCSI Heights
Cheras, Kuala Lumpur 56000
Malaysia

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