Implementing Toxicity Testing in the 21st Century: Challenges and Opportunities

20, International Journal of Risk Assessment and Management, 198 (2017)

28 Pages Posted: 7 Apr 2017

See all articles by Paul Locke

Paul Locke

Johns Hopkins University

Margit Westphal

University of Ottawa

Joyce Tischler

Animal Legal Defense Fund

Kathy Hessler

George Washington University Law School

Pamela Frasch

Lewis & Clark Law School

Bruce Myers

Animals | Environment PLLC

Daniel Krewski

University of Ottawa - Institution of Population Health

Date Written: 2017

Abstract

The publication of the US National Academy of Sciences report Toxicity Testing in the Twenty-First Century: A Vision and a Strategy (TT21C) has led to the development of new scientific techniques to modernize regulatory toxicity testing. From 2009 to 2010, a series of five international symposia were held to examine challenges, opportunities and policy issues associated with TT21C. Seven key themes emerged based on these meetings; that the TT21C vision and strategy: 1) is not self-implementing; 2) demands new toxicology techniques; 3) has a number of scientific knowledge gaps that need to be filled; 4) requires evaluation of the new tests to determine relevance, reliability, validity and regulatory acceptance by government agencies; 5) can be implemented under TSCA and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) as currently written; 6) requires multi-stakeholder input and commitment; 7) should harmonize acceptance of test data and methods on an international level.

Keywords: risk assessment, risk management, toxicity pathway, Toxic Substances Control Act, TSCA, environmental agents, REACH, EU Cosmetic act

JEL Classification: K00

Suggested Citation

Locke, Paul and Westphal, Margit and Tischler, Joyce and Hessler, Kathy and Frasch, Pamela and Myers, Bruce and Krewski, Daniel, Implementing Toxicity Testing in the 21st Century: Challenges and Opportunities (2017). 20, International Journal of Risk Assessment and Management, 198 (2017), Available at SSRN: https://ssrn.com/abstract=2928986

Paul Locke

Johns Hopkins University ( email )

Baltimore, MD 20036-1984
United States

Margit Westphal

University of Ottawa ( email )

2292 Edwin Crescent
Ottawa, Ontario K2C 1H7
Canada

Joyce Tischler

Animal Legal Defense Fund ( email )

Kathy Hessler (Contact Author)

George Washington University Law School ( email )

2000 H St NW
Washington, DC 20052

Pamela Frasch

Lewis & Clark Law School ( email )

10015 S.W. Terwilliger Blvd.
Portland, OR 97219
United States

Bruce Myers

Animals | Environment PLLC ( email )

1730 M Street, NW, Suite 700
Washington, DC 20036
United States

Daniel Krewski

University of Ottawa - Institution of Population Health ( email )

2292 Edwin Crescent
Ottawa, Ontario K1N 6N5 K2C 1H7
Canada
613-562-5381 (Phone)
613-562-5380 (Fax)

HOME PAGE: https://web.uottawa.ca/uopr/WPN011?jobs=1&key=12655&lang=EN

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