Implementing Toxicity Testing in the 21st Century: Challenges and Opportunities

20, International Journal of Risk Assessment and Management, 198 (2017)

28 Pages Posted: 7 Apr 2017

See all articles by Paul Locke

Paul Locke

Johns Hopkins University

Margit Westphal

University of Ottawa

Joyce Tischler

Animal Legal Defense Fund

Kathy Hessler

Lewis & Clark Law School

Pamela Frasch

Lewis & Clark Law School

Bruce Myers

Animals | Environment PLLC

Daniel Krewski

University of Ottawa - Institution of Population Health

Date Written: 2017

Abstract

The publication of the US National Academy of Sciences report Toxicity Testing in the Twenty-First Century: A Vision and a Strategy (TT21C) has led to the development of new scientific techniques to modernize regulatory toxicity testing. From 2009 to 2010, a series of five international symposia were held to examine challenges, opportunities and policy issues associated with TT21C. Seven key themes emerged based on these meetings; that the TT21C vision and strategy: 1) is not self-implementing; 2) demands new toxicology techniques; 3) has a number of scientific knowledge gaps that need to be filled; 4) requires evaluation of the new tests to determine relevance, reliability, validity and regulatory acceptance by government agencies; 5) can be implemented under TSCA and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) as currently written; 6) requires multi-stakeholder input and commitment; 7) should harmonize acceptance of test data and methods on an international level.

Keywords: risk assessment, risk management, toxicity pathway, Toxic Substances Control Act, TSCA, environmental agents, REACH, EU Cosmetic act

JEL Classification: K00

Suggested Citation

Locke, Paul and Westphal, Margit and Tischler, Joyce and Hessler, Kathy and Frasch, Pamela and Myers, Bruce and Krewski, Daniel, Implementing Toxicity Testing in the 21st Century: Challenges and Opportunities (2017). 20, International Journal of Risk Assessment and Management, 198 (2017), Available at SSRN: https://ssrn.com/abstract=2928986

Paul Locke

Johns Hopkins University ( email )

Baltimore, MD 20036-1984
United States

Margit Westphal

University of Ottawa ( email )

2292 Edwin Crescent
Ottawa, Ontario K2C 1H7
Canada

Joyce Tischler

Animal Legal Defense Fund ( email )

Kathy Hessler (Contact Author)

Lewis & Clark Law School ( email )

10015 S.W. Terwilliger Blvd.
Portland, OR 97219
United States

Pamela Frasch

Lewis & Clark Law School ( email )

10015 S.W. Terwilliger Blvd.
Portland, OR 97219
United States

Bruce Myers

Animals | Environment PLLC ( email )

1730 M Street, NW, Suite 700
Washington, DC 20036
United States

Daniel Krewski

University of Ottawa - Institution of Population Health ( email )

2292 Edwin Crescent
Ottawa, Ontario K1N 6N5 K2C 1H7
Canada
613-562-5381 (Phone)
613-562-5380 (Fax)

HOME PAGE: https://web.uottawa.ca/uopr/WPN011?jobs=1&key=12655&lang=EN

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