Activity-Dependent Model of Axonal Targeting in the Developing Olfactory Bulb Driven by Population Coded Chemosensor Input

Science Direct Working Paper No S1574-034X(04)70272-0

8 Pages Posted: 5 Jun 2017 Last revised: 16 Nov 2018

See all articles by Daljeet Gill

Daljeet Gill

University of Leicester - Department of Engineering

Keith Albert

Tufts University - Department of Chemistry

David R. Walt

Tufts University - Department of Chemistry

Tim Pearce

University of Leicester - Department of Engineering

Date Written: March 2003

Abstract

Two recent studies revealed that odorant-evoked activity-dependent competition is significant in the organisation and maintenance of the olfactory system. In this paper, we investigate the generation of a chemotopic sensory map in the olfactory bulb through three models driven by high-density optical chemosensor arrays which have similar properties to olfactory receptor neurons. By exposing the sensor arrays to various odours and Hebbian learning these models achieve self-organisation, potentially explaining the activity-dependent competition demonstrated by recent experimental studies. Our final model also predicts a role for periglomerular cells in the formation of the chemotopic sensory map.

Keywords: Computational Neuro Science, Computational Neuro Science, Computational Neuro Science, Conferences/0303006

Suggested Citation

Gill, Daljeet and Albert, Keith and Walt, David R. and Pearce, Tim, Activity-Dependent Model of Axonal Targeting in the Developing Olfactory Bulb Driven by Population Coded Chemosensor Input (March 2003). Computer Science Preprint Archive Vol. 2003, Issue 3, pp 99-106. Available at SSRN: https://ssrn.com/abstract=2978385

Daljeet Gill (Contact Author)

University of Leicester - Department of Engineering ( email )

Leicester
United Kingdom

Keith Albert

Tufts University - Department of Chemistry ( email )

Medford, MA 02155
United States

David R. Walt

Tufts University - Department of Chemistry

Medford, MA 02155
United States

Tim Pearce

University of Leicester - Department of Engineering ( email )

Leicester
United Kingdom

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