Biological Effects of Imidazolium Ionic Liquids with Varying Chain Lenghts in Acute and Wst-1 Cell Viability Assays
Science Direct Working Paper No S1574-0331(04)70629-3
27 Pages Posted: 14 Jun 2017 Last revised: 13 Jan 2018
Date Written: March 2003
Detailed biological studies of methyl- and some ethylimidazolium ionic liquids in luminescent bacteria as well as in the IPC-81 (leukemia cells) and C6 (glioma cells) rat cell lines are presented. Effect concentrations in these test systems are generally some orders of magnitude lower than the toxicity of the conventional solvents acetone, acetonitrile, methanol and methyl tert-butyl ether. No general influence of the anionic compound in the ionic liquids on toxicity could be found, although they seem to modulate toxicity in some cases. The clear influence of the alkyl chain length on toxicity was quantified by linear regression analysis. Alkyl chain length of the longer alkyl chain length was varied from three to ten carbon atoms. Consequences for a design of sustainable alternative solvents are briefly sketched.
Keywords: Imidazolium, ionic liquids, alternative solvents, toxicity, Vibrio fischeri, leukemia cell lines
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