Biological Effects of Imidazolium Ionic Liquids with Varying Chain Lenghts in Acute and Wst-1 Cell Viability Assays

Science Direct Working Paper No S1574-0331(04)70629-3

27 Pages Posted: 14 Jun 2017 Last revised: 13 Jan 2018

See all articles by Johannes Ranke

Johannes Ranke

University of Bremen - Center for Environmental Research and Environmental Technology

K. Mölter

University of Bremen - Center for Environmental Research and Environmental Technology

F. Stock

University of Bremen - Center for Environmental Research and Environmental Technology

U. Bottin-Weber

University of Bremen - Center for Environmental Research and Environmental Technology

J. Poczobutt

University of Bremen - Center for Environmental Research and Environmental Technology

J. Hoffmann

Institute for Technical Chemistry and Environmental Chemistry (ITUC)

B. Ondruschka

Institute for Technical Chemistry and Environmental Chemistry (ITUC)

J. Filser

University of Bremen - Center for Environmental Research and Environmental Technology

B. Jastorff

University of Bremen - Center for Environmental Research and Environmental Technology

Date Written: March 2003

Abstract

Detailed biological studies of methyl- and some ethylimidazolium ionic liquids in luminescent bacteria as well as in the IPC-81 (leukemia cells) and C6 (glioma cells) rat cell lines are presented. Effect concentrations in these test systems are generally some orders of magnitude lower than the toxicity of the conventional solvents acetone, acetonitrile, methanol and methyl tert-butyl ether. No general influence of the anionic compound in the ionic liquids on toxicity could be found, although they seem to modulate toxicity in some cases. The clear influence of the alkyl chain length on toxicity was quantified by linear regression analysis. Alkyl chain length of the longer alkyl chain length was varied from three to ten carbon atoms. Consequences for a design of sustainable alternative solvents are briefly sketched.

Keywords: Imidazolium, ionic liquids, alternative solvents, toxicity, Vibrio fischeri, leukemia cell lines

Suggested Citation

Ranke, Johannes and Mölter, K. and Stock, F. and Bottin-Weber, U. and Poczobutt, J. and Hoffmann, J. and Ondruschka, B. and Filser, J. and Jastorff, B., Biological Effects of Imidazolium Ionic Liquids with Varying Chain Lenghts in Acute and Wst-1 Cell Viability Assays (March 2003). Chemistry Preprint Archive Vol. 2003, Issue 3, pp 84-110. Available at SSRN: https://ssrn.com/abstract=2979753

Johannes Ranke (Contact Author)

University of Bremen - Center for Environmental Research and Environmental Technology ( email )

Bremen, D-28359
Germany

K. Mölter

University of Bremen - Center for Environmental Research and Environmental Technology

Bremen, D-28359
Germany

F. Stock

University of Bremen - Center for Environmental Research and Environmental Technology

Bremen, D-28359
Germany

U. Bottin-Weber

University of Bremen - Center for Environmental Research and Environmental Technology

Bremen, D-28359
Germany

J. Poczobutt

University of Bremen - Center for Environmental Research and Environmental Technology

Bremen, D-28359
Germany

J. Hoffmann

Institute for Technical Chemistry and Environmental Chemistry (ITUC)

Jena
Germany

B. Ondruschka

Institute for Technical Chemistry and Environmental Chemistry (ITUC)

Jena
Germany

J. Filser

University of Bremen - Center for Environmental Research and Environmental Technology

Bremen, D-28359
Germany

B. Jastorff

University of Bremen - Center for Environmental Research and Environmental Technology

Bremen, D-28359
Germany

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