Studi In Silico Afinitas Katinon dan Metabolitnya terhadap Reseptor Dopamin D1 dan D2 (In Silico Study Affinities of Cathinone and Metabolites Towards Dopamine D1 and D2 Receptors)

Proceedings of the National Seminar Treatment of Drug Abuse 2016

8 Pages Posted: 9 Aug 2017

Date Written: July 1, 2016

Abstract

Indonesian Abstract: Latar Belakang: Katinon, suatu senyawa narkotika beserta metabolitnya diketahui dapat menstimulasi reseptor dopamin. Kelompok reseptor dopamin adalah reseptor pada susunan saraf pusat yang berfungsi meregulasi level cAMP intraseluler. Stimulasi pada D1-like receptors akan meningkatkan konsentrasi dopamin pada susunan saraf pusat, sedangkan pada D2-like receptors sebaliknya.

Tujuan: Penelitian ini bertujuan untuk mengetahui afinitas senyawa katinon dan metabolitnya terhadap reseptor dopamin D1 dan D2.

Metode: Molecular docking dilakukan pada senyawa katinon, katin, dan norefedrin terhadap D1- like receptors seperti D1 dan D2-like receptors seperti D2.

Hasil Penelitian: Afinitas tertinggi ditunjukkan oleh katinon dan seluruh metabolitnya terhadap reseptor D1, dengan energi bebas ikatan paling negatif dan konstanta inhibisi paling kecil diberikan oleh katinon, secara berturut-turut sebesar -6,56 kcal/mol dan 15,54 µM. Seluruh metabolit katinon menunjukkan afinitas yang lebih rendah dibandingkan katinon terhadap reseptor dopamin, baik pada reseptor D1 dan D2.

Kesimpulan: Hasil tersebut menunjukkan bahwa katinon memiliki afinitas paling tinggi dibanding metabolitnya sebagai stimulan reseptor dopamin. Hasil ini juga menunjukkan bahwa katinon dan metabolitnya memiliki afinitas lebih tinggi pada D1-like receptors sehingga cenderung menstimulasi peningkatan konsentrasi dopamin.

English Abstract: Background: Cathinone, a drug compounds and its metabolites were known to stimulate dopamine receptors. Dopamine receptors were CNS receptors with function to regulates intracellular cAMP levels. Stimulation of D1-like receptors would increase the concentration of dopamine level in CNS, contrary with D2-like receptors.

Objective: This study aims to determine the affinity of cathinone and metabolites against dopamine receptors D1 and D2.

Method: Molecular docking was performed on cathinone and metabolites like cathine and norephedrine against D1-like receptors such as D1 and D2-like receptors such as D2.

Results: The highest affinity shown by cathinone and metabolites against D1, with cathinone provide most negative free energy of binding and lowest inhibition constants -6.56 kcal/mol and 15.54 µM, respectively. All cathinone’s metabolites provide lower affinity than cathinone against dopamine receptors, including D1 and D2.

Conclusion: This results showed that cathinone had highest affinity than its metabolites toward dopamine receptors. This results also indicate that cathinone and metabolites had higher affinity toward D1-like receptor, which tend to stimulate an increase in the concentration of dopamine.

Note: Downloadable document is in Indonesian.

Keywords: Cathinone, Dopamine Receptors, Molecular Docking

Suggested Citation

Pratama, Mohammad Rizki Fadhil, Studi In Silico Afinitas Katinon dan Metabolitnya terhadap Reseptor Dopamin D1 dan D2 (In Silico Study Affinities of Cathinone and Metabolites Towards Dopamine D1 and D2 Receptors) (July 1, 2016). Proceedings of the National Seminar Treatment of Drug Abuse 2016. Available at SSRN: https://ssrn.com/abstract=3007708

Mohammad Rizki Fadhil Pratama (Contact Author)

Universitas Muhammadiyah Palangkaraya ( email )

RTA Milono Street Km. 1.5
Palangka Raya, Central Kalimantan 73111
Indonesia

HOME PAGE: http://www.umpalangkaraya.ac.id

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