Weight Reduction with Improvement of Serum Lipid Profile and Ratios of Sesamum Radiatum Leaves Diet in a Non-Obese Sprague Dawley Rats

African Journal of Biotechnology, 2007

2 Pages Posted: 18 Aug 2017

See all articles by Lukeman Shittu

Lukeman Shittu

Jireh Laboratories International LLC; Houston Community College, Department of Biology; University of Abuja, Department of Anatomical Sciences; Benue State University, Department of Anatomy; Lagos State University - Department of Anatomy

Munir Bankole

University of Lagos

O Ogundipe

Obafemi Awolowo University

A. Falade

Lagos State University - Teaching Hospital

Remilekun Shittu

Bolomedics Laboratories

M. Bankole

Nigerian Institute of Medical Research

Titilade Ahmed

Lagos State University - Teaching Hospital

O.A. Ashiru

Lagos State University - Department of Anatomy

Adetokunbo Tayo

Lagos University Teaching Hospital

Date Written: November 10, 2007

Abstract

Development of novel natural dietary adjunct/agent with significant therapeutic effects on metabolic disease conditions such as obesity and heart disease raises concern in recent times. We studied chronic toxicity of the combined active ingredients present in the sesame leaves and their interaction on the fasting serum lipid profiles with their ratios in thirty adult male non-obese Sprague Dawley (SD) rats. Such that, both treated groups received 14.0 and 28.0 mg/kg body weight doses of aqueous leaves extract of Sesamum radiatum respectively on a daily basis via gastric gavage, while, the control received equal volume of normal saline daily for six weeks. Significant (P < 0.05) weight loss observed in the treated groups was associated with significant (P < 0.05) reductions in both serum cholesterol and triglycerides (TG). The effect on the serum lipoprotein cholesterol components and ratios were significant in a dose related manner, such that increase in HDL accompanied a corresponding decrease in both LDL and LDL/HDL ratio. In addition, to increased in TG/HDL ratio. However, no significant differences in the relative reduction level of VLDL and triglycerides in the treated groups were found compared to control. Thus, LDL/HDL ratio is significantly a better indicator than the TG/HDL ratio in assessing the impact of sesame treatment with evidence of weight loss and hypolipidaemia especially in hypertensive heart diseases. .

Keywords: Sesame leaves, Weight loss, SD rats, Phytoestrogens, Lignans, GC/MS, hypolipidemia, TG/HDL

JEL Classification: I10, Q10

Suggested Citation

Shittu, Lukeman and Bankole, Munir and Ogundipe, O and Falade, A. and Shittu, Remilekun and Bankole, M. and Ahmed, Titilade and Ashiru, O.A. and Tayo, Adetokunbo, Weight Reduction with Improvement of Serum Lipid Profile and Ratios of Sesamum Radiatum Leaves Diet in a Non-Obese Sprague Dawley Rats (November 10, 2007). African Journal of Biotechnology, 2007. Available at SSRN: https://ssrn.com/abstract=3016990

Lukeman Shittu (Contact Author)

Jireh Laboratories International LLC ( email )

P.O.BOX 1813
ALIEF, TX HOUSTON 77411
United States
346-322-5042 (Phone)

HOME PAGE: http://linkedin.com/in/drlukemanjosephshittu

Houston Community College, Department of Biology ( email )

3100 Main Street
Houston, TX Harris County 77002
United States

HOME PAGE: http://linkedin.com/in/drlukemanjosephshittu

University of Abuja, Department of Anatomical Sciences ( email )

Airport Road Giri
Gwagalada
F.C.T, West Africa 00234
Nigeria

HOME PAGE: http://linkedin.com/in/drlukemanjosephshittu

Benue State University, Department of Anatomy ( email )

Along Gboko Rd, P.M.B.102119 Makurdi-Gboko Rd
Makurdi, 97001
Nigeria

HOME PAGE: http://linkedin.com/in/drlukemanjosephshittu

Lagos State University - Department of Anatomy ( email )

Ikeja, Lagos
Nigeria

Munir Bankole

University of Lagos ( email )

Akoka
Yaba
Lagos, Lagos state 234
Nigeria

O Ogundipe

Obafemi Awolowo University ( email )

P.M.B 13
Ile-Ife, Osun 230001
Nigeria

A. Falade

Lagos State University - Teaching Hospital ( email )

Lagos
Nigeria

Remilekun Shittu

Bolomedics Laboratories ( email )

Egbeda, Lagos
Nigeria

M. Bankole

Nigerian Institute of Medical Research ( email )

Edmund Cres
Lagos
Nigeria

Titilade Ahmed

Lagos State University - Teaching Hospital ( email )

Lagos
Nigeria

O.A. Ashiru

Lagos State University - Department of Anatomy

Ikeja, Lagos
Nigeria

Adetokunbo Tayo

Lagos University Teaching Hospital ( email )

Idi-Araba,Surulere
Lagos, PMB 12003
Nigeria

Register to save articles to
your library

Register

Paper statistics

Downloads
4
Abstract Views
62
PlumX Metrics