Neonatal Polychlorinated Biphenyls-Induced Endocrine Dysfunction

Annals of Thyroid Research, Vol. 2, Issue 1, 2016

2 Pages Posted: 15 Aug 2017

See all articles by Ahmed R. G.

Ahmed R. G.

Beni Suef University - Zoology Department

Date Written: January 15, 2016

Abstract

The final conclusion is that the administration of PCB 95 seems to lead to thyroid adipokine dysfunction. These changes may be either directly or indirectly related to TH action. I hypothesized that if the endocrine system is disrupted earlier in development, then it is more likely to persist into adulthood. This may cause a persistent hypothyroidism and disrupt the hypothalamic neural circuitry and estrogenic activity. More interestingly, the toxicity of PCBs is dependent on compound congeners, dose, exposure duration, developmental period, and the species involved. I also observed the importance of further studies on implications at later life stages following the hormonal alteration occurring in the developing infants. Further investigations are required to elucidate the potential associations with human health.

Suggested Citation

R. G., Ahmed, Neonatal Polychlorinated Biphenyls-Induced Endocrine Dysfunction (January 15, 2016). Annals of Thyroid Research, Vol. 2, Issue 1, 2016. Available at SSRN: https://ssrn.com/abstract=3017853

Ahmed R. G. (Contact Author)

Beni Suef University - Zoology Department ( email )

Beni Suef
Egypt

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