Neonatal Polychlorinated Biphenyls-Induced Endocrine Dysfunction
Annals of Thyroid Research, Vol. 2, Issue 1, 2016
2 Pages Posted: 15 Aug 2017
Date Written: January 15, 2016
The final conclusion is that the administration of PCB 95 seems to lead to thyroid adipokine dysfunction. These changes may be either directly or indirectly related to TH action. I hypothesized that if the endocrine system is disrupted earlier in development, then it is more likely to persist into adulthood. This may cause a persistent hypothyroidism and disrupt the hypothalamic neural circuitry and estrogenic activity. More interestingly, the toxicity of PCBs is dependent on compound congeners, dose, exposure duration, developmental period, and the species involved. I also observed the importance of further studies on implications at later life stages following the hormonal alteration occurring in the developing infants. Further investigations are required to elucidate the potential associations with human health.
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