Effects of Zinc Supplementation in Neonatal Hypothyroidism and Cerebellar Distortion Induced by Maternal Carbimazole

Asian Journal of Applied Sciences, Volume 4, Issue 4, August 2016

11 Pages Posted: 15 Aug 2017

See all articles by A. El-Ghareeb

A. El-Ghareeb

Cairo University - Zoology Department

A. El-Bakry

Beni Suef University - Zoology Department

Ahmed R. G.

Beni Suef University - Zoology Department

Asmaa Gaber

Beni Suef University - Zoology Department

Date Written: August 12, 2016

Abstract

The aim of this study is to investigate the protective role of Zn on thyroid function and cerebellum impairments induced by carbimazole (CMI) in neonats at PND 28. Animals were divided into four groups: group I acts as control; group II received carbimazole(1.35mg/kg.b.wCMI) only; group III received Zn as zinc sulphate (3mg/kg.b.w) and group IV received Zn and CMI. The administration of maternal CMI caused significant decrease in serum T4, T3 and growth hormone (GH) levels and significant increase in serum TSH levels in both dams and their newborns relative to control group. While in Zinc-hypothyroid group, a reverse pattern was noticed for all previous parameters comparing with hypothyroid group. Maternal CMI administration caused significant decrease in GSH, SOD, GPX, CAT and t-SH of cerebellum and increased prooxidant levels including MDA, H2O2 and NO while Zn administration to hypothyroid dams reversed this effect. CMI administration caused some degeneration and deformation in newborns cerebellum while zinc supplementation to CMI group enhanced structure, length, number and size of purkinje cells, also increase size of the granular layer. Our results indicated that zinc has an improvement role on THs levels and histoarchiture of cerebellumdue to its antioxidant role.

Keywords: Carbimazole, Zinc, Thyroid Hormones, Antioxidant, Prooxidant

Suggested Citation

El-Ghareeb, A. and El-Bakry, A. and R. G., Ahmed and Gaber, Asmaa, Effects of Zinc Supplementation in Neonatal Hypothyroidism and Cerebellar Distortion Induced by Maternal Carbimazole (August 12, 2016). Asian Journal of Applied Sciences, Volume 4, Issue 4, August 2016. Available at SSRN: https://ssrn.com/abstract=3017897

A. El-Ghareeb

Cairo University - Zoology Department ( email )

Giza
Egypt

A. El-Bakry

Beni Suef University - Zoology Department ( email )

Beni Suef
Egypt

Ahmed R. G. (Contact Author)

Beni Suef University - Zoology Department ( email )

Beni Suef
Egypt

Asmaa Gaber

Beni Suef University - Zoology Department

Beni Suef
Egypt

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