Lactating PTU Exposure: II-Alters Thyroid-Axis and Prooxidant-Antioxidant Balance in Neonatal Cerebellum

International Research Journal of Natural Sciences, Vol. 2, No. 1, pp. 1-20, March 2014

20 Pages Posted: 15 Aug 2017

See all articles by Ahmed R. G.

Ahmed R. G.

Beni Suef University - Zoology Department

A. El-Gareib

Cairo University

S. Incerpi

University of Rome III

Date Written: March 12, 2014

Abstract

The aim of the present study was to evaluate the effect of lactating 6-propyl-2- thiouracil (PTU) on the interactions between the thyroid-axis and prooxidant/antioxidant markers in neonates. PTU was administered to female rats in drinking water (0.1% w/v) from birth to lactation day (LD) 30. The administration gave rise to a highly significant decrease in serum thyroxine (T4) and triiodothyronine (T3) levels and increase in serum thyrotropin (TSH) level in both dams and their offspring at LDs 20 and 30 relative to control group. Also, in PTU group, a marked depression was observed in serum of neonatal growth hormone (GH). In this hypothyroid state, obvious elevation of oxidative markers (protein carbonyls, lipid peroxidation, NO and H2O2) was observed at postnatal days (PNDs) 20 and 30, along with decreased activities of antioxidants markers (total thiol, glutathione, glutathione peroxidase, superoxide dismutase and catalase) in neonatal cerebellum with respect to control group. Also, the administration caused some histopathological changes in neonatal cerebellar cortex, such as oedema, vacuoles, reduction of the Purkinje cells, and cellular fragmentations at PND 30. Thus, hypothyroidism in lactating PTU impairs the neonatal neuroendocrine system via production of free radicals, and this, may cause damage of proteins and lipids at the plasma membrane and cellular components delaying cerebellum development.

Keywords: 6-Propyl-2-Thiouracil, Thyroid, Cerebellum, Antioxidants, Prooxidant, Rat Newborns

Suggested Citation

R. G., Ahmed and El-Gareib, A. and Incerpi, S., Lactating PTU Exposure: II-Alters Thyroid-Axis and Prooxidant-Antioxidant Balance in Neonatal Cerebellum (March 12, 2014). International Research Journal of Natural Sciences, Vol. 2, No. 1, pp. 1-20, March 2014. Available at SSRN: https://ssrn.com/abstract=3017911

Ahmed R. G. (Contact Author)

Beni Suef University - Zoology Department ( email )

Beni Suef
Egypt

A. El-Gareib

Cairo University

Orman
Giza
Egypt

S. Incerpi

University of Rome III ( email )

Via Ostiense, 159
Rome, RM 00145
Italy

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