Key Challenges in Bringing CRISPR-Mediated Somatic Cell Therapy into the Clinic

Nicol, Dianne; Eckstein, Lisa; Morrison, Michael; Sherkow, Jacob S.; Otlowski, Margaret; Whitton, Tess; Bubela, Tania; Burdon, Kathryn; Chalmers, Donald; Chan, Sarah; Charlesworth, Jacqueline; Critchley, Christine; Crossley, Merlin; de Lacey, Sheryl; Dickinson, Joanne; Hewitt, Alex; Liddicoat, John; Kamens, Joanne; Kato, Kazuto; Kleiderman, Erica; Kodama, Satoshi; Mackey, David; Newson, Ainsley; Nielsen, Jane L; Wagner, Jennifer; McWhirter, Rebekah

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Key Challenges in Bringing CRISPR-Mediated Somatic Cell Therapy into the Clinic

Genome Medicine, 2017

4 Pages Posted: 18 Oct 2017

See all articles by Dianne Nicol

Michael Morrison

University of Oxford - Centre for Health, Law and Emerging Technologies

University of Illinois College of Law; Carle Illinois College of Medicine; University of Illinois at Urbana-Champaign - Carl R. Woese Institute for Genomic Biology; Center for Advanced Studies in Biomedical Innovation Law

Margaret Otlowski

University of Tasmania - Faculty of Law

Tess Whitton

University of Tasmania

Tania Bubela

University of Alberta - Faculty of Public Health

Kathryn Burdon

University of Tasmania

Donald Chalmers

University of Tasmania - Faculty of Law; University of Sydney - Centre for Values, Ethics and the Law in Medicine

Sarah Chan

University of Manchester - Centre for Social Ethics and Policy

Jacqueline Charlesworth

University of Tasmania - Menzies Institute for Medical Research

Christine Critchley

Swinburne University of Technology

Merlin Crossley

University of New South Wales (UNSW)

Sheryl de Lacey

Flinders University

Joanne Dickinson

University of Tasmania

Alex Hewitt

University of Tasmania

John Liddicoat

King’s College London; University of Cambridge - Faculty of Law; University of Tasmania

Joanne Kamens

Addgene

Kazuto Kato

Osaka, Dept of Biomedical Ethics & Public Policy, Graduate School of Medicine; Kyoto University, Institute for Integrated Cell-Material Sciences

Erica Kleiderman

McGill University

Satoshi Kodama

Kyoto University

David Mackey

University of Western Australia - Centre for Ophthalmology and Visual Science

Ainsley Newson

The University of Sydney

Jane L Nielsen

University of Tasmania

Jennifer Wagner

Geisinger Health System - Bioethics Research

Rebekah McWhirter

Deakin University - School of Medicine; University of Tasmania

Date Written: September 25, 2017

Abstract

Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.

Keywords: Genome Editing, CRISPR, Somatic Cell Therapy, Genetic Diseases, Gene Therapy

Suggested Citation: Suggested Citation

Nicol, Dianne and Eckstein, Lisa and Morrison, Michael and Sherkow, Jacob S. and Otlowski, Margaret and Whitton, Tess and Bubela, Tania and Burdon, Kathryn and Chalmers, Donald and Chan, Sarah and Charlesworth, Jacqueline and Critchley, Christine and Crossley, Merlin and de Lacey, Sheryl and Dickinson, Joanne and Hewitt, Alex and Liddicoat, Johnathon and Kamens, Joanne and Kato, Kazuto and Kleiderman, Erica and Kodama, Satoshi and Mackey, David and Newson, Ainsley and Nielsen, Jane L and Wagner, Jennifer and McWhirter, Rebekah, Key Challenges in Bringing CRISPR-Mediated Somatic Cell Therapy into the Clinic (September 25, 2017). Genome Medicine, 2017, Available at SSRN: https://ssrn.com/abstract=3050477