Therapeutic Translation of Genomic Science: Opportunities and Limitations of Gwas

39 Pages Posted: 6 Nov 2017

See all articles by Manuel Hermosilla

Manuel Hermosilla

Johns Hopkins University - Carey Business School

Jorge Lemus

University Of Illinois Urbana Champaign

Date Written: November 2017

Abstract

Many scientists predicted a swift revolution in human therapeutics after the completion of the Human Genome Project (“HGP”). This revolution, however, has been slow to materialize in spite of the scientific advances. We investigate the role of biological complexity in slowing down this revolution. Our test relies on a disease-specific measure of biological complexity, constructed by drawing on insights from Network Medicine (Barabási et al., 2011). According to our measure, more complex diseases are associated with a larger number of genetic mutations—higher centrality in the Human Disease Network (Goh et al., 2007). With this measure in hand, we estimate the rate of translation of new science into early-stage drug innovation by focusing on a leading type of genetic epidemiological knowledge (Genome-Wide Association Studies), and employing standard methods for the measurement of R&D productivity. For less complex diseases, we find a strong and positive association between cumulative knowledge and the amount of innovation. This association weakens as complexity increases, becoming statistically insignificant at the extreme. Our results suggest that biological complexity is, in part, responsible for the slower-than-expected unfolding of the therapeutical revolution set in motion by the HGP.

Suggested Citation

Hermosilla, Manuel and Lemus, Jorge, Therapeutic Translation of Genomic Science: Opportunities and Limitations of Gwas (November 2017). NBER Working Paper No. w23989, Available at SSRN: https://ssrn.com/abstract=3065801

Manuel Hermosilla (Contact Author)

Johns Hopkins University - Carey Business School ( email )

100 International Drive
Baltimore, MD 21202
United States

Jorge Lemus

University Of Illinois Urbana Champaign ( email )

1407 Gregory Drive, DKH 214
Urbana, IL 61801
United States

HOME PAGE: http://sites.google.com/site/jorgelemuswebsite/

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