Hybrid Ceramo-Polymeric Nanocomposite for Biomimetic Scaffolds Design and Preparation

American Journal of Engineering and Applied Sciences, 2016, 9(4)

10 Pages Posted: 22 Nov 2017

See all articles by Raffaella Aversa

Raffaella Aversa

Advanced Material Lab - Department of Architecture and Industrial Design

Relly Victoria Petrescu

Polytechnic University of Bucharest - ARoTMM-IFToMM

Roberto Sorrentino

Advanced Material Lab

Florian Ion Petrescu

Polytechnic University of Bucharest - ARoTMM-IFToMM

Antonio Apicella

Advanced Material Lab - Department of Architecture and Industrial Design

Date Written: November 20, 2017

Abstract

Biomimetics, biomechanics and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability. Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico). An innovative biomimetics and biomechanics approach and new synthetic structure providing a microenvironment, which is mechanically coherent and nutrient conducive for tissue osteoblast cell cultures used in regenerative medicine, are presented. The novel hybrid ceramo-polymeric nanocomposites are mutually investigated by Finite Element Analysis (FEA) biomimetic modelling, anatomic reconstruction, quantitative-computed-tomography characterization, computer design of tissue scaffold. The starting base materials are a class of innovative highly bioactive hybrid ceramo-polymeric materials set-up by the proponent research group that will be used as bioactive matrix for the preparation of in situ bio-mineralised tecto-structured porous nanocomposites. This study treats biomimetics, biomechanics and tissue engineering as strongly correlated multidisciplinary fields combined to design bone tissue scaffolds. The growth, maintenance and ossification of bone are fundamental and are regulated by the mechanical cues that are imposed by physical activities: This biomimetical/biomechanical approach will be pursued in designing the experimental procedures for in vitro scaffold mineralization and ossification. Bio-tissue mathematical modelling serves as a central repository to interface design, simulation and tissue fabrication. Finite element computer analyses will be used to study the role of local tissue mechanics on endochondral ossification patterns, skeletal morphology and mandible thickness distributions using single and multi-phase continuum material representations of clinical cases of patients implanted with the traditional protocols. New protocols will be hypothesises for the use of the new biologically tecto-structured hybrid materials.

Note: © 2016 Raffaella Aversa, Relly Victoria V. Petrescu, Roberto Sorrentino, Florian Ion T. Petrescu and Antonio Apicella. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Suggested Citation

Aversa, Raffaella and Petrescu, Relly Victoria and Sorrentino, Roberto and Petrescu, Florian Ion and Apicella, Antonio, Hybrid Ceramo-Polymeric Nanocomposite for Biomimetic Scaffolds Design and Preparation (November 20, 2017). American Journal of Engineering and Applied Sciences, 2016, 9(4). Available at SSRN: https://ssrn.com/abstract=3074483

Raffaella Aversa

Advanced Material Lab - Department of Architecture and Industrial Design ( email )

81031 Aversa (CE)
Italy

Relly Victoria Petrescu

Polytechnic University of Bucharest - ARoTMM-IFToMM ( email )

Romania

Roberto Sorrentino

Advanced Material Lab ( email )

81031 Aversa (CE)
Italy

Florian Ion Petrescu (Contact Author)

Polytechnic University of Bucharest - ARoTMM-IFToMM ( email )

Romania

Antonio Apicella

Advanced Material Lab - Department of Architecture and Industrial Design ( email )

81031 Aversa (CE)
Italy

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