Design of Antiretroviral Peptidomimetic Oligopeptides from HIV-1 Proviral Reverse Complement ORFs
14 Pages Posted: 2 Jan 2018
Date Written: December 23, 2017
Goal: This paper introduces a method of employing genomic data to design oligopeptides as Peptidomimetic agents those that are chemically-related bioactive compounds exhibiting possible therapeutic properties for discovery of novel Retroviral Protease Binding Peptides. Purpose: The research has been undertaken to explore the possibilities of designing novel drug targets using oligopeptide(s) derived from proviral cDNA of HIV-1 genome.
Materials and Method: We employ analytical methods and tools of genomic and proteomic analysis to investigate the nucleotide sequences from HIV-1 proviral cDNA and utilize the ORF translation data to design, screen, and match relevant oligopeptides that might have therapeutic applications closely related to the subclasses of inhibitors of retroviral proteases.
Results: Following analysis and screening of ORFs translational data that include amino acid analysis and other parameters of interest, the resultant oligopeptides were matched with the chemical databases to sort out the most relevant equivalents that mimic retroviral protease inhibitors. We found several compounds of interest that might have possible therapeutic implications. Further screening and modeling of the compounds are being attempted that may yield promising results.
Conclusion: We derive several oligopeptide compounds out of which one compond that might be considered for experimental validation.
Keywords: HIV-1, ORF, Peptidomimetics, Oligopeptides, Retroviral protease, ARV
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