Investigating Fractional Exhaled Nitric Oxide (FeNO) in Chronic Obstructive Pulmonary Disease (COPD) and Asthma–COPD Overlap (ACO): A Scoping Review Protocol

BMJ Open 2017;7:e018954. DOI:10.1136/bmjopen-2017-018954

Posted: 27 Dec 2017

See all articles by Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi

Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada

Nafiseh Naderi

McGill University - Division of Experimental Medicine; Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada

Miriam Barrecheguren

McGill University

Abolfazl Dehghan

Islamic Azad University (IAU)

Jean Bourbeau

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada

Date Written: December 24, 2017

Abstract

Introduction: During the last decade, many articles have been published, including reviews on fractional exhaled nitric oxide (FeNO) use and utility in clinical practice and for monitoring and identifying eosinophilic airway inflammation, especially in asthma, and evaluating corticosteroid responsiveness. However, the exact role of FeNO in patients with chronic obstructive pulmonary disease (COPD) and its ability to distinguish patients with COPD and those having concomitant asthma, that is, asthma–COPD overlap (ACO) is still unclear and needs to be defined. Due to the broad topics of FeNO in chronic airway disease, we undertook a scoping review. The present article describes the protocol of a scoping review of peer-reviewed published literature specific to FeNO in COPD/ACO over the last decade.

Methods and analysis: We used Joanna Briggs Institute Reviewers’ Manual scoping review methodology as well as Levac et al’s and Arksey et al’s framework as guides. We searched a variety of databases, including Medline, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library, Web of Science, and BioSciences Information Service (BIOSIS) on 29 June 2016. Additional studies will be recognised by exploring the reference list of identified eligible studies. Screening of eligible studies will be independently performed by two reviewers and any disagreement will be solved by the third reviewer. We will analyse the gathered data from article bibliographies and abstracts.

Ethics and dissemination: To investigate the body of published studies regarding the role of FeNO in patients with COPD and its usefulness in the clinical setting, a scoping review can be used as a modern and pioneer model, which does not need ethics approval. By this review, new insights for conducting new research specific to FeNO in COPD/ ACO population will emerge. The results of this study will be reported in the scientific meetings and conferences, which aim to provide information to the clinicians, primary care providers and basic science researchers.

Suggested Citation

Mostafavi-Pour-Manshadi, Seyed-Mohammad-Yousof and Naderi, Nafiseh and Barrecheguren, Miriam and Dehghan, Abolfazl and Bourbeau, Jean, Investigating Fractional Exhaled Nitric Oxide (FeNO) in Chronic Obstructive Pulmonary Disease (COPD) and Asthma–COPD Overlap (ACO): A Scoping Review Protocol (December 24, 2017). BMJ Open 2017;7:e018954. DOI:10.1136/bmjopen-2017-018954. Available at SSRN: https://ssrn.com/abstract=3092900

Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi (Contact Author)

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada ( email )

Montreal, Quebec
Canada

Nafiseh Naderi

McGill University - Division of Experimental Medicine ( email )

Montreal, Quebec
Canada

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada ( email )

Miriam Barrecheguren

McGill University ( email )

1001 Sherbrooke St. W
Montreal, Quebec H3A 1G5
Canada

Abolfazl Dehghan

Islamic Azad University (IAU) ( email )

Hamedan, Iran
Tehran, Isfahan 461-15655
Iran

Jean Bourbeau

Respiratory Epidemiology and Clinical Research Unit, Research Institute of McGill University Health Centre, McGill University, Montreal, Canada ( email )

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