Interactions Between Ubiquitin-Proteasome System and Autophagy
IJBCB Next Research Note 1, January 2018
6 Pages Posted: 23 Jan 2018
Date Written: January 9, 2018
This Research Note investigates the reciprocal interaction between the ubiquitin-proteasome system (UPS) and macroautophagy using the Euretos AI platform.
Analysis of the UPS mediation of macroautophagy, identified various E3 ubiquitin protein ligases actually targeting proteins involved in phagophore nucleation and elongation, mediating the autophagy process. Enrichment analysis of these E3 enzymes leads to the hypothesis that DNA damage leads to activation of the p53 and ATM pathways which drive cell cycle arrest and ubiquitination of key autophagy initiating proteins.
Regarding autophagic mediation of UPS, the analysis identified several proteasome related proteins which interact with key molecules driving autophagic sequestration, suggesting that the proteasome complex is degraded by autophagy. Enrichment analysis of these enzymes leads to the hypothesis that autophagy of the Proteasome complex appears to be associated with oxidative stress and cytotoxicity driving caspase activity inducing apoptosis.
Keywords: Proteasome; Autophagy; Microautophagy; DNA Damage
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