Human Stakeholders and the Use of Animals in Drug Development

56 Pages Posted: 12 Mar 2018

See all articles by Lisa A. Kramer

Lisa A. Kramer

University of Toronto - Rotman School of Management

Ray Greek

Americans for Medical Advancement A.F.M.A.

Date Written: Spring 2018

Abstract

Pharmaceutical firms seek to fulfill their responsibilities to stakeholders by developing drugs that treat diseases. We evaluate the social and financial costs of developing new drugs relative to the realized benefits and find the industry falls short of its potential. This is primarily due to legislation‐mandated reliance on animal test results in early stages of the drug development process, leading to a mere 10 percent success rate for new drugs entering human clinical trials. We cite hundreds of biomedical studies from journals including Nature, Science, and the Journal of the American Medical Association to show animal modeling is ineffective, misleading to scientists, unable to prevent the development of dangerous drugs, and prone to prevent the development of useful drugs. Legislation still requires animal testing prior to human testing even though the pharmaceutical sector has better options that were unavailable when animal modeling was first mandated. We propose that the U.S. Food and Drug Administration (FDA) and Congress should work together to abolish regulations and policies that require animal use. Doing so will benefit pharmaceutical industry stakeholders, including patients whose health depends on drugs and the many people who rely on the financial well‐being of pharmaceutical firms.

Suggested Citation

Kramer, Lisa A. and Greek, Ray, Human Stakeholders and the Use of Animals in Drug Development (Spring 2018). Business and Society Review, Vol. 123, Issue 1, pp. 3-58, 2018. Available at SSRN: https://ssrn.com/abstract=3136693 or http://dx.doi.org/10.1111/basr.12134

Lisa A. Kramer (Contact Author)

University of Toronto - Rotman School of Management ( email )

105 St. George Street
Toronto, Ontario M5S 3E6 M5S1S4
Canada
416-978-2496 (Phone)
416-971-3048 (Fax)

HOME PAGE: http://www.chass.utoronto.ca/~lkramer

Ray Greek

Americans for Medical Advancement A.F.M.A. ( email )

2251 Refugio Road
Goleta, CA 93117
United States

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