Pharmacological Investigation of Anticonvulsant Activity of Sesamum Indicum Linn. 50% Enol Leaves Extract

Pharmacological Investigation of Anticonvulsant Activity of Sesamum indicum Linn. 50% Ethanol Leaves Extract www.rjptonline.org Research J. Pharm. and Tech. 4(12): Dec. 2011

Posted: 30 Nov 2018 Last revised: 7 Aug 2019

Date Written: August 22, 2011

Abstract

The anticonvulsant activity of 50% ethanol leave extract of Sesamum indicum (ESI) were investigated on various animal models including Strychnine nitrate (SN) induced seizure, Pentylenetetrazole (PTZ) induced seizure, Maximal electroshock seizure model in mice .ESI (100 and 200 mg/kg) produce dose dependent and Significant (P<0.05) increases in onset to clonic and tonic convulsions and at 400 mg/kg showed complete protection against seizure induced by strychnine but not with pentylenetetrazole. 50% ethanol extract of Sesamum indicum protected mice against tonic convulsions induced by Maximal electroshock.

Keywords: Anticonvulsant, Sesamum Indicum, Ethanol

Suggested Citation

Chaurasia, Vikas and Kumar, Praveen, Pharmacological Investigation of Anticonvulsant Activity of Sesamum Indicum Linn. 50% Enol Leaves Extract (August 22, 2011). Pharmacological Investigation of Anticonvulsant Activity of Sesamum indicum Linn. 50% Ethanol Leaves Extract www.rjptonline.org Research J. Pharm. and Tech. 4(12): Dec. 2011. Available at SSRN: https://ssrn.com/abstract=3149019

Vikas Chaurasia (Contact Author)

VBS Purvanchal University ( email )

Shahganj Road
Jaunpur, Uttar Pradesh 222001
India
+91-9415894006 (Phone)

Praveen Kumar

Independent ( email )

No Address Available

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