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Induction and maintenance of CX3CR1-intermediate peripheral memory CD8 T cells by persistent viruses and novel vaccines

50 Pages Posted: 2 Apr 2018 Publication Status: Published

See all articles by Claire L. Gordon

Claire L. Gordon

University of Oxford - Peter Medawar Building for Pathogen Research

Lian Ni Lee

University of Oxford - Peter Medawar Building for Pathogen Research

Leo Swadling

University of Oxford - Peter Medawar Building for Pathogen Research

Claire Hutchings

University of Oxford - Peter Medawar Building for Pathogen Research

Madeleine Zinser

University of Oxford - Peter Medawar Building for Pathogen Research

Andrew J. Highton

University of Oxford - Peter Medawar Building for Pathogen Research

Stefania Capone

Reithera Srl

Antonella Folgori

University of Oxford - Peter Medawar Building for Pathogen Research

Eleanor Barnes

affiliation not provided to SSRN

Paul Klenerman

University of Oxford - Peter Medawar Building for Pathogen Research

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Abstract

The induction and maintenance of T-cell memory is critical to the success of novel vaccines. A newlydescribed subset of memory CD8 T-cells defined by intermediate expression of the chemokine receptor CX3CR1, were shown to have self-renewal, proliferative and tissue-surveillance properties relevant to vaccine-induced memory. We tracked these cells in situations where memory is sustained at high levels – memory “inflation” induced by cytomegalovirus (CMV) and adenovirus-vectored vaccines. In mice, both CMV and vaccine-induced inflationary T-cells showed sustained high levels of CX3R1int cells exhibiting an effector-memory phenotype, characteristic of inflationary pools. In humans, CX3CR1int CD8 T-cells were strongly induced following administration of an adenovirus-vectored vaccine for HCV (ChAd3-NSmut) and during natural CMV infection, and were associated with a memory phenotype similar to that in mice. These data indicate that CX3CR1int memory cells form a substantial component of the memory pool in response to persistent viruses and vaccines in both mouse and man.

Suggested Citation

Gordon, Claire L. and Lee, Lian Ni and Swadling, Leo and Hutchings, Claire and Zinser, Madeleine and Highton, Andrew J. and Capone, Stefania and Folgori, Antonella and Barnes, Eleanor and Klenerman, Paul, Induction and maintenance of CX3CR1-intermediate peripheral memory CD8 T cells by persistent viruses and novel vaccines (2018). Available at SSRN: https://ssrn.com/abstract=3151996 or http://dx.doi.org/10.2139/ssrn.3151996
This version of the paper has not been formally peer reviewed.

Claire L. Gordon

University of Oxford - Peter Medawar Building for Pathogen Research

South Parks Road
OX2 3SY
United Kingdom

Lian Ni Lee

University of Oxford - Peter Medawar Building for Pathogen Research

South Parks Road
OX2 3SY
United Kingdom

Leo Swadling

University of Oxford - Peter Medawar Building for Pathogen Research

South Parks Road
OX2 3SY
United Kingdom

Claire Hutchings

University of Oxford - Peter Medawar Building for Pathogen Research

South Parks Road
OX2 3SY
United Kingdom

Madeleine Zinser

University of Oxford - Peter Medawar Building for Pathogen Research

South Parks Road
OX2 3SY
United Kingdom

Andrew J. Highton

University of Oxford - Peter Medawar Building for Pathogen Research

South Parks Road
OX2 3SY
United Kingdom

Stefania Capone

Reithera Srl

Viale Città D'Europa 679
Rome, 00144
Italy

Antonella Folgori

University of Oxford - Peter Medawar Building for Pathogen Research

South Parks Road
OX2 3SY
United Kingdom

Eleanor Barnes

affiliation not provided to SSRN

Paul Klenerman (Contact Author)

University of Oxford - Peter Medawar Building for Pathogen Research ( email )

South Parks Road
OX2 3SY
United Kingdom

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