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Coordination-Responsive Drug Release inside Gold Nanorod@MOF for NIR-Induced Synergistic Chemo-Photothermal Therapy

43 Pages Posted: 2 Apr 2018 Sneak Peek Status: Review Complete

See all articles by Yantao Li

Yantao Li

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

Jun Jin

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

Dawei Wang

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

Jiawei Lv

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

Ke Hou

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

Yaling Liu

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

Chunying Chen

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

Zhiyong Tang

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

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Abstract

Multifunctional core-shell nanostructures by integration of distinct components have received wide attention as a promising biological platform in recent years. In this work, the crystalline zeolitic imidazolate framework-8 (ZIF-8), a typical metal-organic framework (MOF), is coated onto single gold nanorod (AuNR) core for successful realization of synergistic photothermal and chemotherapy triggered by near-infrared (NIR) light. Impressively, the high doxorubicin hydrochloride (DOX) loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented through formation and breakage of coordination bonds in the system. Moreover, under 808 nm NIR laser irradiation, these novel core-shell NP@MOF nanostructures exhibit effective chemo-photothermal synergistic therapy both in vitro and in vivo, confirmed by both cell treatment and tumor ablation via intravenous injection.

Suggested Citation

Li, Yantao and Jin, Jun and Wang, Dawei and Lv, Jiawei and Hou, Ke and Liu, Yaling and Chen, Chunying and Tang, Zhiyong, Coordination-Responsive Drug Release inside Gold Nanorod@MOF for NIR-Induced Synergistic Chemo-Photothermal Therapy (2018). Available at SSRN: https://ssrn.com/abstract=3151999 or http://dx.doi.org/10.2139/ssrn.3151999
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Yantao Li

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Jun Jin

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Dawei Wang

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Jiawei Lv

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Ke Hou

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Yaling Liu

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication ( email )

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Chunying Chen

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication ( email )

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Zhiyong Tang (Contact Author)

Chinese Academy of Sciences (CAS) - Key Laboratory of Nanosystem and Hierarchical Fabrication ( email )

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

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