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Decoding a Decision Process in the Neuronal Population of Dorsal Premotor Cortex

46 Pages Posted: 10 Apr 2018 Sneak Peek Status: Review Complete

See all articles by Román Rossi-Pool

Román Rossi-Pool

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

Antonio Zainos

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

Manuel Alvarez

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

Jerónimo Zizumbo

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

José Vergara

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

Ranulfo Romo

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

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Abstract

When trained monkeys discriminate the temporal structure of two sequential vibrotactile stimuli, dorsal premotor cortex (DPC) showed high heterogeneity among its neuronal responses. Notably, DPC neurons coded the stimulus patterns as broader categories and signaled them during the working memory, comparison and postponed decision periods in this task. Here, we show that these responses can be condensed to population dynamics within two major components: one that persistently represented in working memory both the identity of the initial sensory representation and the postponed informed choice, and another that coded transiently the comparison of the two stimulus patterns. Further analysis showed that these two components interacted, providing a compact and intuitive idea of what the DPC circuit is dynamically coding in this task. This interaction, hidden by heterogeneity, is captured only by the population dynamics and not by the single neuronal responses.

Suggested Citation

Rossi-Pool, Román and Zainos, Antonio and Alvarez, Manuel and Zizumbo, Jerónimo and Vergara, José and Romo, Ranulfo, Decoding a Decision Process in the Neuronal Population of Dorsal Premotor Cortex (2018). Available at SSRN: https://ssrn.com/abstract=3155890 or http://dx.doi.org/10.2139/ssrn.3155890
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Román Rossi-Pool (Contact Author)

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular ( email )

Cto. Exterior s/n, Cd. Universitaria
Mexico City, 04510
Mexico

Antonio Zainos

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

Cto. Exterior s/n, Cd. Universitaria
Mexico City, 04510
Mexico

Manuel Alvarez

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

Cto. Exterior s/n, Cd. Universitaria
Mexico City, 04510
Mexico

Jerónimo Zizumbo

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

Cto. Exterior s/n, Cd. Universitaria
Mexico City, 04510
Mexico

José Vergara

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular

Cto. Exterior s/n, Cd. Universitaria
Mexico City, 04510
Mexico

Ranulfo Romo

National Autonomous University of Mexico (UNAM) - Instituto de Fisiología Celular ( email )

Cto. Exterior s/n, Cd. Universitaria
Mexico City, 04510
Mexico

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