Insilico Anti-Inflammatory Activity of Dibutylphthalate

5 Pages Posted: 26 Apr 2018

See all articles by Lavanya latha Yerraguravagari

Lavanya latha Yerraguravagari

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Applied Microbiology

Vasavi Thirumalanadhuni

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Applied Microbiology

Mathakala Vani

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Applied Microbiology

Devi Maheswari

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Applied Microbiology

Date Written: February 7, 2018

Abstract

In response to inflammatory stimuli by bacterial lipopolysaccharide, COX-2 induces the production of prostaglandins and thromboxanes. The Overexpression of COX-2 has been associated with high levels of PGE2 and the modulation of COX-2 and iNOS reduces the inflammation process. The objective of this investigation was to determine the binding mechanism of dibutylphthalate with COX-2 and with mPGES-1.The docking studies were carried out and the inhibitor binding positions and affinity were evaluated using Auto dock 4. We observed that amino acid residues Arg120, Ala527 and Ser530 in COX-2 and Arg38 in mPGES-1 are important for inhibitor recognition via hydrogen bonding interactions.

Keywords: COX-2, mPGES-1 Marine Streptomyces carpaticus, Dibutyl phthalate

Suggested Citation

Yerraguravagari, Lavanya latha and Thirumalanadhuni, Vasavi and Vani, Mathakala and Maheswari, Devi, Insilico Anti-Inflammatory Activity of Dibutylphthalate (February 7, 2018). 2018 IADS International Conference on Computing, Communications & Data Engineering (CCODE) 7-8 February. Available at SSRN: https://ssrn.com/abstract=3167809 or http://dx.doi.org/10.2139/ssrn.3167809

Lavanya latha Yerraguravagari (Contact Author)

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Applied Microbiology ( email )

Padmavathi Nagar, Near West Railway Station,
Andhra Pradesh
Tirupati, Andhra Pradesh 517502
India

Vasavi Thirumalanadhuni

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Applied Microbiology ( email )

Padmavathi Nagar, Near West Railway Station,
Andhra Pradesh
Tirupati, Andhra Pradesh 517502
India

Mathakala Vani

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Applied Microbiology ( email )

Padmavathi Nagar, Near West Railway Station,
Andhra Pradesh
Tirupati, Andhra Pradesh 517502
India

Devi Maheswari

Sri Padmavati Mahila Visvavidyalayam (SPMVV) - Department of Applied Microbiology ( email )

Padmavathi Nagar, Near West Railway Station,
Andhra Pradesh
Tirupati, Andhra Pradesh 517502
India

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