Estrogen Regulates the Satellite Cell Compartment in Females

51 Pages Posted: 16 Jun 2018

See all articles by Brittany Collins

Brittany Collins

University of Minnesota - Minneapolis - Division of Physical Therapy; University of Minnesota - Minneapolis - Department of Rehabilitation Medicine

Robert Arpke

University of Minnesota - Minneapolis - Department of Pediatrics; University of Minnesota - Minneapolis - Lillehei Heart Institute

Alexie Larson

University of Minnesota - Minneapolis - Department of Integrative Biology and Physiology

Cory Baumann

University of Minnesota - Minneapolis - Division of Physical Therapy; University of Minnesota - Minneapolis - Department of Rehabilitation Medicine

Christine Cabelka

University of Minnesota - Minneapolis - Division of Physical Therapy; University of Minnesota - Minneapolis - Department of Rehabilitation Medicine

Nardina Nash

University of Minnesota - Minneapolis - Department of Rehabilitation Medicine; University of Minnesota - Minneapolis - Division of Physical Therapy

Hanna Juppi

University of Jyväskylä - Gerontology Research Center

Eija Laakkonen

University of Jyväskylä - Gerontology Research Center

Sarianna Sipila

University of Jyväskylä - Gerontology Research Center

Vuokko Kovanen

University of Jyväskylä - Gerontology Research Center

Espen Spangenburg

East Carolina University - East Carolina Diabetes and Obesity Institute

Michael Kyba

University of Minnesota - Minneapolis - Lillehei Heart Institute; University of Minnesota - Minneapolis - Department of Pediatrics

Dawn Lowe

University of Minnesota - Minneapolis - Department of Rehabilitation Medicine; University of Minnesota - Minneapolis - Division of Physical Therapy

Date Written: May 1, 2018

Abstract

Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing greater deterioration in females about the time estrogen levels decrease at menopause. Here we show that maintenance of muscle stem cells, satellite cells, as well as self-renewal and differentiation into muscle fibers, are severely compromised by estrogen deficiency. Mechanistically, by hormone replacement, use of a selective estrogen-receptor modulator (bazedoxifene), and conditional estrogen receptor knockout, we implicate 17β-estradiol and satellite cell expression of estrogen receptor alpha (ERalpha) and show that estrogen signaling through this receptor is necessary to prevent apoptosis of satellite cells. Early data from a biopsy study of women who transitioned from peri- to post-menopause are consistent with the loss of satellite cells coincident with the decline in estradiol in humans. Together, these results demonstrate an important role for estrogen in satellite cell maintenance and muscle regeneration in females.

Keywords: estradiol, muscle stem cells, ovarian hormones, quiescence, skeletal muscle

Suggested Citation

Collins, Brittany and Arpke, Robert and Larson, Alexie and Baumann, Cory and Cabelka, Christine and Nash, Nardina and Juppi, Hanna and Laakkonen, Eija and Sipila, Sarianna and Kovanen, Vuokko and Spangenburg, Espen and Kyba, Michael and Lowe, Dawn, Estrogen Regulates the Satellite Cell Compartment in Females (May 1, 2018). Available at SSRN: https://ssrn.com/abstract=3188128 or http://dx.doi.org/10.2139/ssrn.3188128

Brittany Collins

University of Minnesota - Minneapolis - Division of Physical Therapy ( email )

MMC 388
420 Delaware Street SE
Minneapolis, MN 55455
United States

University of Minnesota - Minneapolis - Department of Rehabilitation Medicine ( email )

500 Boynton Health Service Bridge
410 Church St.
Minneapolis, MN 55455
United States

Robert Arpke

University of Minnesota - Minneapolis - Department of Pediatrics ( email )

2450 Riverside Avenue
6th Floor, East Building
Minneapolis, MN 55455
United States

University of Minnesota - Minneapolis - Lillehei Heart Institute ( email )

2231 6th Street SE
4-156 CCRB 2812A
Minneapolis, MN 55455
United States

Alexie Larson

University of Minnesota - Minneapolis - Department of Integrative Biology and Physiology ( email )

Jackson Hall 6-125
321 Church St. SE
Minneapolis, MN 55455
United States

Cory Baumann

University of Minnesota - Minneapolis - Division of Physical Therapy ( email )

MMC 388
420 Delaware Street SE
Minneapolis, MN 55455
United States

University of Minnesota - Minneapolis - Department of Rehabilitation Medicine ( email )

500 Boynton Health Service Bridge
410 Church St.
Minneapolis, MN 55455
United States

Christine Cabelka

University of Minnesota - Minneapolis - Division of Physical Therapy ( email )

MMC 388
420 Delaware Street SE
Minneapolis, MN 55455
United States

University of Minnesota - Minneapolis - Department of Rehabilitation Medicine ( email )

500 Boynton Health Service Bridge
410 Church St.
Minneapolis, MN 55455
United States

Nardina Nash

University of Minnesota - Minneapolis - Department of Rehabilitation Medicine ( email )

500 Boynton Health Service Bridge
410 Church St.
Minneapolis, MN 55455
United States

University of Minnesota - Minneapolis - Division of Physical Therapy ( email )

MMC 388
420 Delaware Street SE
Minneapolis, MN 55455
United States

Hanna Juppi

University of Jyväskylä - Gerontology Research Center ( email )

Building Liikunta (L)
Keskussairaalankatu 4
Jyväskylä
Finland

Eija Laakkonen

University of Jyväskylä - Gerontology Research Center ( email )

Building Liikunta (L)
Keskussairaalankatu 4
Jyväskylä
Finland

Sarianna Sipila

University of Jyväskylä - Gerontology Research Center ( email )

Building Liikunta (L)
Keskussairaalankatu 4
Jyväskylä
Finland

Vuokko Kovanen

University of Jyväskylä - Gerontology Research Center ( email )

Building Liikunta (L)
Keskussairaalankatu 4
Jyväskylä
Finland

Espen Spangenburg

East Carolina University - East Carolina Diabetes and Obesity Institute ( email )

115 Heart Drive, 4101 ECHI
Greenville, SC 27834
United States

Michael Kyba

University of Minnesota - Minneapolis - Lillehei Heart Institute ( email )

2231 6th Street SE
4-156 CCRB 2812A
Minneapolis, MN 55455
United States

University of Minnesota - Minneapolis - Department of Pediatrics ( email )

2450 Riverside Avenue
6th Floor, East Building
Minneapolis, MN 55455
United States

Dawn Lowe (Contact Author)

University of Minnesota - Minneapolis - Department of Rehabilitation Medicine ( email )

500 Boynton Health Service Bridge
410 Church St.
Minneapolis, MN 55455
United States

University of Minnesota - Minneapolis - Division of Physical Therapy ( email )

MMC 388
420 Delaware Street SE
Minneapolis, MN 55455
United States

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