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Hair Regeneration by Small Molecules That Activate Autophagy

21 Pages Posted: 1 Jun 2018 Sneak Peek Status: Review Complete

See all articles by Min Chai

Min Chai

University of California, Los Angeles (UCLA) - Molecular Biology Interdisciplinary Graduate Program

Meisheng Jiang

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

Laurent Vergnes

University of California, Los Angeles (UCLA) - Department of Human Genetics

Xudong Fu

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

Stéphanie C. de Barros

University of California, Los Angeles (UCLA) - Department of Pathology and Laboratory Medicine

Jing Jiao

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

Harvey R. Herschman

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

Gay M. Crooks

University of California, Los Angeles (UCLA) - Department of Pathology and Laboratory Medicine

Karen Reue

University of California, Los Angeles (UCLA) - Department of Human Genetics

Jing Huang

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

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Abstract

Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions worldwide and can occur because of aging, hormonal dysfunction, autoimmunity, or as a side effect of cancer treatment. Methods that can be used to regrow hair are highly sought after, but lacking. Here we report that hair regeneration can be stimulated by small molecules that activate autophagy, including the longevity metabolites α-ketoglutarate and α-ketobutyrate, and the prescription drugs rapamycin and metformin which impinge on TOR and AMPK signaling.

Suggested Citation

Chai, Min and Jiang, Meisheng and Vergnes, Laurent and Fu, Xudong and de Barros, Stéphanie C. and Jiao, Jing and Herschman, Harvey R. and Crooks, Gay M. and Reue, Karen and Huang, Jing, Hair Regeneration by Small Molecules That Activate Autophagy (2018). Available at SSRN: https://ssrn.com/abstract=3188356 or http://dx.doi.org/10.2139/ssrn.3188356
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Min Chai

University of California, Los Angeles (UCLA) - Molecular Biology Interdisciplinary Graduate Program

405 Hilgard Avenue
Box 951361
Los Angeles, CA 90095
United States

Meisheng Jiang

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

1000 Veteran Avenue, Box 956939
Los Angeles, CA 90095-6939
United States

Laurent Vergnes

University of California, Los Angeles (UCLA) - Department of Human Genetics

695 Charles E. Young Drive South
Los Angeles, CA 90095-7088
United States

Xudong Fu

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

1000 Veteran Avenue, Box 956939
Los Angeles, CA 90095-6939
United States

Stéphanie C. De Barros

University of California, Los Angeles (UCLA) - Department of Pathology and Laboratory Medicine

50-082 UCLA Center for the Health Sciences
Los Angeles, CA 90095
United States

Jing Jiao

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

1000 Veteran Avenue, Box 956939
Los Angeles, CA 90095-6939
United States

Harvey R. Herschman

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP)

1000 Veteran Avenue, Box 956939
Los Angeles, CA 90095-6939
United States

Gay M. Crooks

University of California, Los Angeles (UCLA) - Department of Pathology and Laboratory Medicine

50-082 UCLA Center for the Health Sciences
Los Angeles, CA 90095
United States

Karen Reue

University of California, Los Angeles (UCLA) - Department of Human Genetics

695 Charles E. Young Drive South
Los Angeles, CA 90095-7088
United States

Jing Huang (Contact Author)

University of California, Los Angeles (UCLA) - Department of Molecular and Medical Pharmacology (DMMP) ( email )

1000 Veteran Avenue, Box 956939
Los Angeles, CA 90095-6939
United States