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Distinct Sets of Internal, External, and Control Connector Hubs Integrate Human Brain Function

37 Pages Posted: 6 Jun 2018 Sneak Peek Status: Under Review

See all articles by Evan M. Gordon

Evan M. Gordon

Government of the United States of America - VISN 17 Center of Excellence for Research on Returning War Veterans; University of Texas at Dallas - Center for Vital Longevity; Baylor University - Department of Psychology and Neuroscience

Charles J. Lynch

Georgetown University - Department of Psychology

Caterina Gratton

Washington University in St. Louis - Department of Neurology

Timothy O. Laumann

Washington University in St. Louis - Department of Neurology

Adrian W. Gilmore

Washington University in St. Louis - Department of Psychological and Brain Sciences; Government of the United States of America - Laboratory of Brain and Cognition

Deanna J. Greene

Washington University in St. Louis - Department of Radiology; Washington University in St. Louis - Mallinckrodt Institute of Radiology; Washington University in St. Louis - Department of Psychiatry

Mario Ortega

Washington University in St. Louis - Department of Neurology

Annie L. Nguyen

Washington University in St. Louis - Department of Neurology

Bradley L. Schlaggar

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Mallinckrodt Institute of Radiology; Washington University in St. Louis - Department of Radiology; (Formerly Department of Anatomy and Neurobiology; Washington University in St. Louis - Department of Pediatrics; Washington University in St. Louis - Department of Psychiatry

Steven E. Petersen

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Department of Psychological and Brain Sciences; Washington University in St. Louis - Mallinckrodt Institute of Radiology; (Formerly Department of Anatomy and Neurobiology; Washington University in St. Louis - Department of Biomedical Engineering; Washington University in St. Louis - Department of Neurosurgery

Nico U.F. Dosenbach

Washington University in St. Louis - Department of Neurology; Washington University in St. Louis - Program in Occupational Therapy; Washington University in St. Louis - Mallinckrodt Institute of Radiology; Washington University in St. Louis - Department of Pediatrics; Washington University in St. Louis - Department of Biomedical Engineering

Steven M. Nelson

Government of the United States of America - VISN 17 Center of Excellence for Research on Returning War Veterans; University of Texas at Dallas - Center for Vital Longevity; Baylor University - Department of Psychology and Neuroscience

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Abstract

Control over behavior is enabled by the brain's control networks, which interact with lower-level processing networks to regulate their functions. Such interactions are facilitated by specialized "connector hub" regions that interconnect discrete networks. Previous work has treated hubs as a single category of brain regions, though their unitary nature is dubious when examined in individual brains. Here, we investigated the nature of hubs by using functional magnetic resonance imaging to characterize individual-specific hub regions in two independent datasets. We identified separable sets of Internal, External, and Control connector hubs that integrate information between specific brain networks. These three hub categories occupy different positions within the brain's network structure; they impact networks differently when artificially lesioned; and they are differentially engaged during cognitive and motor task performance. This work suggests a model of brain organization in which different connector hubs integrate control functions and enable top-down control of separate processing streams.

Suggested Citation

Gordon, Evan M. and Lynch, Charles J. and Gratton, Caterina and Laumann, Timothy O. and Gilmore, Adrian W. and Greene, Deanna J. and Ortega, Mario and Nguyen, Annie L. and Schlaggar, Bradley L. and Petersen, Steven E. and Dosenbach, Nico U.F. and Nelson, Steven M., Distinct Sets of Internal, External, and Control Connector Hubs Integrate Human Brain Function (2018). Available at SSRN: https://ssrn.com/abstract=3188401 or http://dx.doi.org/10.2139/ssrn.3188401
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Evan M. Gordon (Contact Author)

Government of the United States of America - VISN 17 Center of Excellence for Research on Returning War Veterans ( email )

Doris Miller VA Medical Center
4800 Memorial Drive (151C)
Waco, TX 76711
United States

University of Texas at Dallas - Center for Vital Longevity ( email )

1600 Viceroy Drive Suit 800
Dallas, TX 75235
United States

Baylor University - Department of Psychology and Neuroscience ( email )

One Bear Place 97334
Waco, TX 76798-7334
United States

Charles J. Lynch

Georgetown University - Department of Psychology

306N White-Gravenor Hall
37th and O Streets, N.W.
Washington, DC 20057
United States

Caterina Gratton

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Timothy O. Laumann

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Adrian W. Gilmore

Washington University in St. Louis - Department of Psychological and Brain Sciences

1 Brookings Drive
St. Louis, MO 63130
United States

Government of the United States of America - Laboratory of Brain and Cognition

9000 Rockville Pike
Bethesda, MD 20892
United States

Deanna J. Greene

Washington University in St. Louis - Department of Radiology

3635 Vista Blvd.
St. Louis, MO 63110
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Washington University in St. Louis - Department of Psychiatry

660 S. Euclid Avenue
St. Louis, MO 63110
United States

Mario Ortega

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Annie L. Nguyen

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Bradley L. Schlaggar

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Washington University in St. Louis - Department of Radiology

3635 Vista Blvd.
St. Louis, MO 63110
United States

(Formerly Department of Anatomy and Neurobiology

One Brookings Drive
St. Louis, MO 63130
United States

Washington University in St. Louis - Department of Pediatrics

660 South Euclid Avenue
Campus Box 8208
St. Louis, MO 63130
United States

Washington University in St. Louis - Department of Psychiatry

660 S. Euclid Avenue
St. Louis, MO 63110
United States

Steven E. Petersen

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Washington University in St. Louis - Department of Psychological and Brain Sciences

1 Brookings Drive
St. Louis, MO 63130
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

(Formerly Department of Anatomy and Neurobiology

One Brookings Drive
St. Louis, MO 63130
United States

Washington University in St. Louis - Department of Biomedical Engineering

One Brookings Drive
Campus Box 1208
Saint Louis, MO 63130-4899
United States

Washington University in St. Louis - Department of Neurosurgery

660 S. Euclid Ave., CB 8057
St. Louis, MO 63110
United States

Nico U.F. Dosenbach

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Washington University in St. Louis - Program in Occupational Therapy

4444 Forest Park Ave.
St. Louis, MO 63108
United States

Washington University in St. Louis - Mallinckrodt Institute of Radiology

St. Louis, MO
United States

Washington University in St. Louis - Department of Pediatrics

660 South Euclid Avenue
Campus Box 8208
St. Louis, MO 63130
United States

Washington University in St. Louis - Department of Biomedical Engineering

One Brookings Drive
Campus Box 1208
Saint Louis, MO 63130-4899
United States

Steven M. Nelson

Government of the United States of America - VISN 17 Center of Excellence for Research on Returning War Veterans

Doris Miller VA Medical Center
4800 Memorial Drive (151C)
Waco, TX 76711
United States

University of Texas at Dallas - Center for Vital Longevity

1600 Viceroy Drive Suit 800
Dallas, TX 75235
United States

Baylor University - Department of Psychology and Neuroscience

One Bear Place 97334
Waco, TX 76798-7334
United States

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